A baromfipestis-(Newcastle-betegség) vakcinák rokonsági viszonyai és története

Translated title of the contribution: Relationships and history of live Newcastle disease vaccine strains

Research output: Contribution to journalArticle

Abstract

Formerly, NDV (Newcastle disease virus) strains were classified solely on the basis of virulence, but recently grouping based on genetic relationships of strains are the method of choice. Live vaccine strains belong to mild (lentogenic) or moderately virulent (mesogenic) categories, as opposed to the highly pathogenic epidemic viruses of the velogenic group. Using their genetic properties and lineage, the placement of vaccine strains in 'the NDV world' can be viewed as described below (Figure 1). 1. Lentogenic vaccine strains are found in two of the dozen or so genotypes of NDV resident in chickens. One of them is the American group II (comprising vaccine strains B-1, LaSota and F), the other is genotype I (with strains Ulster 2C, V4/Queensland and NDV-6/10) also residing in wild water-birds. 2. Mesogenic strains too, are present in only two genotypes: group II (strains Roakin and Komarov) and the Asian genogroup III (strains H and Mukteswar). 3. While vaccine strains of groups I and II are of natural origin, strains H, Mukteswar and Komarov were artificially attenuated as claimed by reports in the 1940s. However, discrepancies were discerned between the actual genetic identity and the postulated origin of mesogenic vaccine strains (Figure 2). a) Since the mesogenic strain H is unrelated to the virulent Herts'33, its ostensible parent, the reduced virulence of H can not be attributed to the egg passage procedures performed in England and even the presence of this strain there is a riddle. b) Strains H and Mukteswar with less than 0.3% nucleotide distance between them must have been derived from the same isolate therefore can not be the result of independent developments in England and India. c) The reduced virulence (mesogenic) of strain H/Mukteswar can not be associated with attenuation either; most likely it is a naturally occurring Indian field isolate. d) The mesogenic strain Komarov, which is said to be attenuated through the intracerebral passage in ducklings of a local velogenic virus in Palestine, is identical with the American (genotype II) vaccine strain Roakin, for which no scientific explanation can be given.

Original languageHungarian
Pages (from-to)361-373
Number of pages13
JournalMagyar Allatorvosok Lapja
Volume130
Issue number6
Publication statusPublished - 2008

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Newcastle Disease
Newcastle disease
Vaccines
Newcastle disease virus
vaccines
Genotype
Virulence
England
Viruses
Queensland
Pedigree
Birds
Ovum
virulence
India
Chickens
genotype
Nucleotides
Water

ASJC Scopus subject areas

  • veterinary(all)

Cite this

A baromfipestis-(Newcastle-betegség) vakcinák rokonsági viszonyai és története. / Lomniczi, B.

In: Magyar Allatorvosok Lapja, Vol. 130, No. 6, 2008, p. 361-373.

Research output: Contribution to journalArticle

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abstract = "Formerly, NDV (Newcastle disease virus) strains were classified solely on the basis of virulence, but recently grouping based on genetic relationships of strains are the method of choice. Live vaccine strains belong to mild (lentogenic) or moderately virulent (mesogenic) categories, as opposed to the highly pathogenic epidemic viruses of the velogenic group. Using their genetic properties and lineage, the placement of vaccine strains in 'the NDV world' can be viewed as described below (Figure 1). 1. Lentogenic vaccine strains are found in two of the dozen or so genotypes of NDV resident in chickens. One of them is the American group II (comprising vaccine strains B-1, LaSota and F), the other is genotype I (with strains Ulster 2C, V4/Queensland and NDV-6/10) also residing in wild water-birds. 2. Mesogenic strains too, are present in only two genotypes: group II (strains Roakin and Komarov) and the Asian genogroup III (strains H and Mukteswar). 3. While vaccine strains of groups I and II are of natural origin, strains H, Mukteswar and Komarov were artificially attenuated as claimed by reports in the 1940s. However, discrepancies were discerned between the actual genetic identity and the postulated origin of mesogenic vaccine strains (Figure 2). a) Since the mesogenic strain H is unrelated to the virulent Herts'33, its ostensible parent, the reduced virulence of H can not be attributed to the egg passage procedures performed in England and even the presence of this strain there is a riddle. b) Strains H and Mukteswar with less than 0.3{\%} nucleotide distance between them must have been derived from the same isolate therefore can not be the result of independent developments in England and India. c) The reduced virulence (mesogenic) of strain H/Mukteswar can not be associated with attenuation either; most likely it is a naturally occurring Indian field isolate. d) The mesogenic strain Komarov, which is said to be attenuated through the intracerebral passage in ducklings of a local velogenic virus in Palestine, is identical with the American (genotype II) vaccine strain Roakin, for which no scientific explanation can be given.",
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