Relationship of adipokines and non-esterified fatty acid to the insulin resistance in non-diabetic individuals

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Abstract

Background: Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR). Aim: To determine semi-quantitatively the impact of serum NEFA, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin, and resistin levels on IR measured by homeostasis model assessment (HOMA-IR). Material/subjects: Seventy-four Caucasian subjects forming 3 age-, and sex-matched groups were included into the study [Group 1 and 2: non-diabetic obese patients, no.= 25, body mass index (BMI): 28-39.9 kg/m2, no.=25, BMI≥40 kg/m2, respectively, and Group 3: 24 healthy, normal weight control subjects]. Methods: Serum levels of NEFA and adipokines as well as other metabolic variables including HOMA-IR were measured. Results: HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-α levels, negatively with adiponectin, with no significant relation to resistin. In multiple regression analyses, of these factors leptin was a strong, IL-6 and adiponectin were weak independent predictors of HOMA-IR, while the others were not significant determinants of HOMA-IR. However, even together, they explained only 35-36% of variance of HOMA-IR. Conclusions: Although IR has associations with many of the investigated parameters, of these, only serum level of leptin, and in lesser degree IL-6 and adiponectin are independent determinants of the severity of IR. Moreover, even together they explain only a minority of variance IR.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalJournal of Endocrinological Investigation
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Adipokines
Insulin Resistance
Fatty Acids
Adiponectin
Leptin
Interleukin-6
Resistin
Serum
Body Mass Index
Tumor Necrosis Factor-alpha
Abdominal Obesity
Waist Circumference
Homeostasis
Research Design
Regression Analysis

Keywords

  • Adiponectin
  • Homeostasis model assessment
  • Insulin resistance
  • Interleukin-6
  • Leptin
  • Non-esterified fatty acid
  • Obesity
  • Resistin
  • Tumor necrosis factor α

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{605b3479099d437ea7be41f4f17562d2,
title = "Relationship of adipokines and non-esterified fatty acid to the insulin resistance in non-diabetic individuals",
abstract = "Background: Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR). Aim: To determine semi-quantitatively the impact of serum NEFA, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin, and resistin levels on IR measured by homeostasis model assessment (HOMA-IR). Material/subjects: Seventy-four Caucasian subjects forming 3 age-, and sex-matched groups were included into the study [Group 1 and 2: non-diabetic obese patients, no.= 25, body mass index (BMI): 28-39.9 kg/m2, no.=25, BMI≥40 kg/m2, respectively, and Group 3: 24 healthy, normal weight control subjects]. Methods: Serum levels of NEFA and adipokines as well as other metabolic variables including HOMA-IR were measured. Results: HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-α levels, negatively with adiponectin, with no significant relation to resistin. In multiple regression analyses, of these factors leptin was a strong, IL-6 and adiponectin were weak independent predictors of HOMA-IR, while the others were not significant determinants of HOMA-IR. However, even together, they explained only 35-36{\%} of variance of HOMA-IR. Conclusions: Although IR has associations with many of the investigated parameters, of these, only serum level of leptin, and in lesser degree IL-6 and adiponectin are independent determinants of the severity of IR. Moreover, even together they explain only a minority of variance IR.",
keywords = "Adiponectin, Homeostasis model assessment, Insulin resistance, Interleukin-6, Leptin, Non-esterified fatty acid, Obesity, Resistin, Tumor necrosis factor α",
author = "A. Peti and A. Juh{\'a}sz and P. Kenyeres and Z. Varga and I. Seres and G. Kov{\'a}cs and G. Paragh and L. Bajnok",
year = "2011",
month = "1",
doi = "10.3275/7025",
language = "English",
volume = "34",
pages = "21--25",
journal = "Journal of Endocrinological Investigation",
issn = "0391-4097",
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TY - JOUR

T1 - Relationship of adipokines and non-esterified fatty acid to the insulin resistance in non-diabetic individuals

AU - Peti, A.

AU - Juhász, A.

AU - Kenyeres, P.

AU - Varga, Z.

AU - Seres, I.

AU - Kovács, G.

AU - Paragh, G.

AU - Bajnok, L.

PY - 2011/1

Y1 - 2011/1

N2 - Background: Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR). Aim: To determine semi-quantitatively the impact of serum NEFA, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin, and resistin levels on IR measured by homeostasis model assessment (HOMA-IR). Material/subjects: Seventy-four Caucasian subjects forming 3 age-, and sex-matched groups were included into the study [Group 1 and 2: non-diabetic obese patients, no.= 25, body mass index (BMI): 28-39.9 kg/m2, no.=25, BMI≥40 kg/m2, respectively, and Group 3: 24 healthy, normal weight control subjects]. Methods: Serum levels of NEFA and adipokines as well as other metabolic variables including HOMA-IR were measured. Results: HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-α levels, negatively with adiponectin, with no significant relation to resistin. In multiple regression analyses, of these factors leptin was a strong, IL-6 and adiponectin were weak independent predictors of HOMA-IR, while the others were not significant determinants of HOMA-IR. However, even together, they explained only 35-36% of variance of HOMA-IR. Conclusions: Although IR has associations with many of the investigated parameters, of these, only serum level of leptin, and in lesser degree IL-6 and adiponectin are independent determinants of the severity of IR. Moreover, even together they explain only a minority of variance IR.

AB - Background: Altered secretion of adipokines and non-esterified fatty acid (NEFA) seems to play a pivotal role in the abdominal obesity-related insulin resistance (IR). Aim: To determine semi-quantitatively the impact of serum NEFA, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin, and resistin levels on IR measured by homeostasis model assessment (HOMA-IR). Material/subjects: Seventy-four Caucasian subjects forming 3 age-, and sex-matched groups were included into the study [Group 1 and 2: non-diabetic obese patients, no.= 25, body mass index (BMI): 28-39.9 kg/m2, no.=25, BMI≥40 kg/m2, respectively, and Group 3: 24 healthy, normal weight control subjects]. Methods: Serum levels of NEFA and adipokines as well as other metabolic variables including HOMA-IR were measured. Results: HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-α levels, negatively with adiponectin, with no significant relation to resistin. In multiple regression analyses, of these factors leptin was a strong, IL-6 and adiponectin were weak independent predictors of HOMA-IR, while the others were not significant determinants of HOMA-IR. However, even together, they explained only 35-36% of variance of HOMA-IR. Conclusions: Although IR has associations with many of the investigated parameters, of these, only serum level of leptin, and in lesser degree IL-6 and adiponectin are independent determinants of the severity of IR. Moreover, even together they explain only a minority of variance IR.

KW - Adiponectin

KW - Homeostasis model assessment

KW - Insulin resistance

KW - Interleukin-6

KW - Leptin

KW - Non-esterified fatty acid

KW - Obesity

KW - Resistin

KW - Tumor necrosis factor α

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U2 - 10.3275/7025

DO - 10.3275/7025

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