Relationship between tumor (T) antigen expression and substituent effects on benzo[a]phenothiazines

Rozália Pusztai, Noboru Motohashi, Cyril Párkányi, Jean Jacques Aaron, Bhattiprolu Kesava Rao, Joseph Molnár

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Human adenovirus, oncogene-type 12 infected HEp-2 cells were exposed to six benzo[a]phenothiazines. 5-Oxo-5H-benzo[a]phenothiazines. 5-oxo-5H-benzo[a]phenothiazine (4) and 6-hydroxy-5-oxo-5H-benzo[a]phenothiazine (5) were moderately toxic. 9-methyl-12H-benzo[a]phenothiazine (2), 10-methyl-12H-benzo[a]phenothiazine (3), 6-methyl-5-oxo-5H-benzo[a]phenothiazine (6), and 12H-benzo[a]phenothiazine (I) were not toxic in the system tested. 6-Methyl-5-oxo-5H-benzo[a]phenothiazine (6) enhanced the expression of viral oncogene product (tumor antigen) in the adenovirus infected cells. 5-Oxo-5H-benzo[a]phenothiazine (4) and 6-hydroxy-5-oxo-5H-benzo[a]phenothiazine (6), with hyperconjugation due to the methyl group, increased the T antigen activity at higher dose concentrations, whereas 6-hydroxy-5-oxo-5H-benzo[a]phenothiazine (5) with a hydroxy substituent had the opposite effect on T antigen expression. The methyl substitution at positions C9 or C10 increased the T antigen expression of adenovirus infected cells.

Original languageEnglish
Pages (from-to)2961-2964
Number of pages4
JournalAnticancer research
Volume16
Issue number5 A
Publication statusPublished - Sep 1 1996

Keywords

  • Benzo[a]phenothiazines
  • Tumor antigen
  • Viral oncogene expression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Pusztai, R., Motohashi, N., Párkányi, C., Aaron, J. J., Rao, B. K., & Molnár, J. (1996). Relationship between tumor (T) antigen expression and substituent effects on benzo[a]phenothiazines. Anticancer research, 16(5 A), 2961-2964.