Relationship between the reversed-phase retention of monotetrazolium and ditetrazolium salts and their physicochemical properties

T. Cserháti, E. Forgács, Sándor Balogh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The lipophilicity and specific hydrophobic surface area of seven monotetrazolium salts and nine ditetrazolium salts have been determined by reversed-phase thin-layer chromatography with ethanol, tetrahydrofuran, and dioxane as organic modifiers. The relationship between the hydrophobicities of the tetrazolium salts and their physicochemical properties were elucidated by principal components analysis. The nature of the organic modifier had a negligible impact on lipophilicity but significantly influenced the specific hydrophobic surface area. Not only the calculated lipophilicity but also the steric parameters and the hydrogen-donor and -acceptor capacity of the substituents were strongly related to retention, indicating the involvement of other than hydrophobic forces in the retention mechanism.

Original languageEnglish
Pages (from-to)446-451
Number of pages6
JournalJournal of Planar Chromatography - Modern TLC
Volume12
Issue number6
Publication statusPublished - Nov 1999

Fingerprint

Salts
Tetrazolium Salts
Thin layer chromatography
Reverse-Phase Chromatography
Hydrophobicity
Thin Layer Chromatography
Principal Component Analysis
Hydrophobic and Hydrophilic Interactions
Principal component analysis
Hydrogen
Ethanol
1,4-dioxane
tetrahydrofuran

Keywords

  • Lipophilicity
  • Monotetrazolium and ditetrazolium salts
  • Reversed-phase TLC
  • Specific hydrophobic surface area

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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abstract = "The lipophilicity and specific hydrophobic surface area of seven monotetrazolium salts and nine ditetrazolium salts have been determined by reversed-phase thin-layer chromatography with ethanol, tetrahydrofuran, and dioxane as organic modifiers. The relationship between the hydrophobicities of the tetrazolium salts and their physicochemical properties were elucidated by principal components analysis. The nature of the organic modifier had a negligible impact on lipophilicity but significantly influenced the specific hydrophobic surface area. Not only the calculated lipophilicity but also the steric parameters and the hydrogen-donor and -acceptor capacity of the substituents were strongly related to retention, indicating the involvement of other than hydrophobic forces in the retention mechanism.",
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AU - Balogh, Sándor

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N2 - The lipophilicity and specific hydrophobic surface area of seven monotetrazolium salts and nine ditetrazolium salts have been determined by reversed-phase thin-layer chromatography with ethanol, tetrahydrofuran, and dioxane as organic modifiers. The relationship between the hydrophobicities of the tetrazolium salts and their physicochemical properties were elucidated by principal components analysis. The nature of the organic modifier had a negligible impact on lipophilicity but significantly influenced the specific hydrophobic surface area. Not only the calculated lipophilicity but also the steric parameters and the hydrogen-donor and -acceptor capacity of the substituents were strongly related to retention, indicating the involvement of other than hydrophobic forces in the retention mechanism.

AB - The lipophilicity and specific hydrophobic surface area of seven monotetrazolium salts and nine ditetrazolium salts have been determined by reversed-phase thin-layer chromatography with ethanol, tetrahydrofuran, and dioxane as organic modifiers. The relationship between the hydrophobicities of the tetrazolium salts and their physicochemical properties were elucidated by principal components analysis. The nature of the organic modifier had a negligible impact on lipophilicity but significantly influenced the specific hydrophobic surface area. Not only the calculated lipophilicity but also the steric parameters and the hydrogen-donor and -acceptor capacity of the substituents were strongly related to retention, indicating the involvement of other than hydrophobic forces in the retention mechanism.

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