A hypothalamus-hypophysis-mellékvese tengely és a metabolikus szindróma kapcsolata

Translated title of the contribution: Relationship between the hypothalamo-pituitary-adrenal axis and the metabolic syndrome

Miklós Góth, Erika Hubina, Márta Korbonits

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The metabolic syndrome has several similarities with Cushing's syndrome (impaired glucose tolerance, hypertension, dyslipidemia, central obesity) suggesting that abnormalities in the regulation of the hypothalamic-pituitary- adrenal axis may have a link with the metabolic syndrome. Several studies suggested an association between the clinical signs of the metabolic syndrome and the increased hypothalamic-pituitary-adrenal axis activity based on increased cortisol concentration at 09.00 a.m. and increased cortisol response to corticotropin. According to the Barker hypothesis the fetal malnutrition could determine adult cardiovascular diseases (coronary heart disease, hypertension), some endocrine and metabolic disorders (obesity, type 2 diabetes and hyperlipidemia). The suggested mechanism of the phenomenon is that the suboptimal fetal nutrition results in glucocorticoid overproduction. The 11β-hydroxysteroid dehydrogenase (converts biological inactive cortisone to cortisol and vice versa) is an important enzyme in cortisol metabolism. The increased expression of 11β-hydroxysteroid dehydrogenase type 1 in fat tissue could lead to central obesity and impaired glucose tolerance. The hypothesis that increased corticotropin-releasing hormone production drives the overactive hypothalamo-pituitary-adrenal axis was not proven. Further investigations are needed to identify additional pathogenetic factors and to find new therapeutic possibilities.

Original languageHungarian
Pages (from-to)51-55
Number of pages5
JournalOrvosi hetilap
Volume146
Issue number2
Publication statusPublished - Dec 1 2005

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ASJC Scopus subject areas

  • Medicine(all)

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