Relationship between the hydrophobic and hydrophilic molecular parameters of some synthetic nucleosides, determined by means of adsorptive and reversed-phase thin-layer chromatography

Tibor Cserháti, Klára Valko

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The adsorption capacity, the specific adsorptive surface, the lipophilicity and the specific hydrophobic surface of 59 natural and synthetic nucleoside derivatives were determined by means of adsorptive chromatography and reversed-phase thin-layer chromatography for the future application of these molecular parameters in quantitative structure-activity relationship studies. Stepwise regression analysis and principal component analysis proved that each of the physico-chemical parameters has a different information content, and their application in the design of new bioactive derivatives is therefore justified.

Original languageEnglish
Pages (from-to)81-95
Number of pages15
JournalJournal of biochemical and biophysical methods
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 1990

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Fingerprint Dive into the research topics of 'Relationship between the hydrophobic and hydrophilic molecular parameters of some synthetic nucleosides, determined by means of adsorptive and reversed-phase thin-layer chromatography'. Together they form a unique fingerprint.

  • Cite this