Relationship between the hydrophobic and hydrophilic molecular parameters of some monoamine oxidase inhibitory drugs, determined by means of adsorptive and reversed-phase thin-layer chromatography

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Abstract

The absorption capacity, the specific hydrophilic surface area, the lipophilicity and the specific hydrophobic surface area of 17 monoamine oxidase inhibitory drugs were determined by means of adsorptive and reversed-phase thin-layer chromotography for future application of these molecular parameters in quantitative structure-activity relationship studies. Principal component analysis suggests that most of the physicochemical parameters have a different information content, and their application in the elucidation of their mode of action is therefore justified.

Original languageEnglish
Pages (from-to)249-264
Number of pages16
JournalJournal of Biochemical and Biophysical Methods
Volume24
Issue number3-4
DOIs
Publication statusPublished - 1994

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Thin layer chromatography
Quantitative Structure-Activity Relationship
Monoamine Oxidase
Reverse-Phase Chromatography
Thin Layer Chromatography
Principal Component Analysis
Specific surface area
Pharmaceutical Preparations
Principal component analysis

Keywords

  • Adsorption capacity
  • Lipophilicity
  • Monoamine oxidase inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

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AB - The absorption capacity, the specific hydrophilic surface area, the lipophilicity and the specific hydrophobic surface area of 17 monoamine oxidase inhibitory drugs were determined by means of adsorptive and reversed-phase thin-layer chromotography for future application of these molecular parameters in quantitative structure-activity relationship studies. Principal component analysis suggests that most of the physicochemical parameters have a different information content, and their application in the elucidation of their mode of action is therefore justified.

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