Relationship between tensile stress and plaque growth after balloon angioplasty treated with and without intracoronary beta-brachytherapy

K. Kozuma, M. A. Costa, M. Sabaté, C. J. Slager, E. Boersma, I. P. Kay, J. P A Marijnissen, S. G. Carlier, J. J. Wentzel, A. Thury, J. M R Ligthart, V. L M A Coen, P. C. Levendag, P. W. Serruys

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aims: We investigated the influence of tensile stress on plaque growth after balloon angioplasty with and without beta-radiation therapy. Methods and Results: Thirty-one consecutive patients successfully treated with balloon angioplasty were analysed qualitatively and quantitatively by means of an ECG-gated three-dimensional intravascular ultrasound post-procedure and at follow-up. Eighteen patients were irradiated with catheter-based beta-radiation (90Sr/90Y source) and 13 were not (control). Studied segments were divided into 2 mm subsegments. Thus 184 irradiated and 111 non-irradiated subsegments were included. Tensile stress was calculated according to Laplace's law. The radiation dose was calculated by means of dose-volume histograms. Plaque growth was positively correlated to tensile stress in both the radiation and control groups (r=0.374, P=0.0001 and r=0.305, P=0.001). Low-dose subsegments (

Original languageEnglish
Pages (from-to)2063-2070
Number of pages8
JournalEuropean Heart Journal
Volume21
Issue number24
DOIs
Publication statusPublished - 2000

Fingerprint

Beta Particles
Balloon Angioplasty
Brachytherapy
Radiation
Growth
Electrocardiography
Radiotherapy
Catheters
Control Groups

Keywords

  • Balloon angioplasty
  • Dose-volume histogram
  • Intracoronary radiation
  • Intravascular ultrasound
  • Plaque growth
  • Tensile stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relationship between tensile stress and plaque growth after balloon angioplasty treated with and without intracoronary beta-brachytherapy. / Kozuma, K.; Costa, M. A.; Sabaté, M.; Slager, C. J.; Boersma, E.; Kay, I. P.; Marijnissen, J. P A; Carlier, S. G.; Wentzel, J. J.; Thury, A.; Ligthart, J. M R; Coen, V. L M A; Levendag, P. C.; Serruys, P. W.

In: European Heart Journal, Vol. 21, No. 24, 2000, p. 2063-2070.

Research output: Contribution to journalArticle

Kozuma, K, Costa, MA, Sabaté, M, Slager, CJ, Boersma, E, Kay, IP, Marijnissen, JPA, Carlier, SG, Wentzel, JJ, Thury, A, Ligthart, JMR, Coen, VLMA, Levendag, PC & Serruys, PW 2000, 'Relationship between tensile stress and plaque growth after balloon angioplasty treated with and without intracoronary beta-brachytherapy', European Heart Journal, vol. 21, no. 24, pp. 2063-2070. https://doi.org/10.1053/euhj.2000.2465
Kozuma, K. ; Costa, M. A. ; Sabaté, M. ; Slager, C. J. ; Boersma, E. ; Kay, I. P. ; Marijnissen, J. P A ; Carlier, S. G. ; Wentzel, J. J. ; Thury, A. ; Ligthart, J. M R ; Coen, V. L M A ; Levendag, P. C. ; Serruys, P. W. / Relationship between tensile stress and plaque growth after balloon angioplasty treated with and without intracoronary beta-brachytherapy. In: European Heart Journal. 2000 ; Vol. 21, No. 24. pp. 2063-2070.
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