Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients

L. Locsey, I. Seres, F. Sztanek, M. Harangi, J. Padra, D. Kovacs, R. Fedor, L. Asztalos, G. Paragh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Paraoxonase lactonase activity protects against homocysteinylation; therefore, it can be a potential contributing factor to prevent atherosclerosis. We aimed to determine paraoxonase and HTLase activities and to clarify the relationship between HTLase activity and some cardiovascular risk factors, such as homocysteine, cystatin C asymmetric dimethylarginine (ADMA), and adipokines both in hemo dialyzed and transplanted patients. Among 114 hemodialyzed, 80 transplanted and 64 healthy control subjects, we investigated body mass index (BMI) as well as fasting serum contents of urea, uric acid, creatinine, cystatin C, homocysteine, glucose, lipids, total protein and albumin. Serum paraoxonase (PON 1) and HTLase activities were measured spectrophotometrically. ADMA, ADPN adiponectin, leptin (LEP) levels was determined with a sandwich enzyme-linked immunosorbent assay method. Dyslipidemic patients showed hypercholesterolemia, and high low-density lipoprotein (LDL); parallel with improved renal function, they displayed decreased cystatin C and homocysteine levels (P

Original languageEnglish
Pages (from-to)3685-3687
Number of pages3
JournalTransplantation Proceedings
Volume45
Issue number10
DOIs
Publication statusPublished - Dec 2013

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Aryldialkylphosphatase
Cystatin C
Adipokines
Homocysteine
Arginine
Transplants
Kidney
Serum
Adiponectin
HDL Lipoproteins
Leptin
Hypercholesterolemia
Uric Acid
LDL Lipoproteins
Urea
Albumins
Fasting
Creatinine
Atherosclerosis
Healthy Volunteers

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Relationship between serum paraoxonase and homocysteine thiolactonase activity, adipokines, and asymmetric dimethyl arginine concentrations in renal transplant patients. / Locsey, L.; Seres, I.; Sztanek, F.; Harangi, M.; Padra, J.; Kovacs, D.; Fedor, R.; Asztalos, L.; Paragh, G.

In: Transplantation Proceedings, Vol. 45, No. 10, 12.2013, p. 3685-3687.

Research output: Contribution to journalArticle

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