Relationship between serum calcium and CA 19-9 levels in colorectal cancer

P. Fuszek, P. Lakatos, A. Tabák, J. Papp, Zsolt Nagy, I. Takács, Henrik Csaba Horvath, Peter Laszlo Lakatos, G. Speer

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aim: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectral cancer and control patients. Methods: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these coatings, as well as the relationship between different CaSR genotypes and the data stated above. Results: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. Conclusion: Based on these results lower levels of serum calcium might be a pothogenic and prognostic factor in colorectal cancer.

Original languageEnglish
Pages (from-to)1890-1892
Number of pages3
JournalWorld Journal of Gastroenterology
Volume10
Issue number13
Publication statusPublished - Jul 1 2004

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Colorectal Neoplasms
Carbohydrates
Calcium
Calcium-Sensing Receptors
Antigens
Serum
Genotype
Vitamin D
Albumins
Control Groups
Population
Genes
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Relationship between serum calcium and CA 19-9 levels in colorectal cancer. / Fuszek, P.; Lakatos, P.; Tabák, A.; Papp, J.; Nagy, Zsolt; Takács, I.; Horvath, Henrik Csaba; Lakatos, Peter Laszlo; Speer, G.

In: World Journal of Gastroenterology, Vol. 10, No. 13, 01.07.2004, p. 1890-1892.

Research output: Contribution to journalArticle

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AU - Lakatos, P.

AU - Tabák, A.

AU - Papp, J.

AU - Nagy, Zsolt

AU - Takács, I.

AU - Horvath, Henrik Csaba

AU - Lakatos, Peter Laszlo

AU - Speer, G.

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N2 - Aim: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectral cancer and control patients. Methods: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these coatings, as well as the relationship between different CaSR genotypes and the data stated above. Results: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. Conclusion: Based on these results lower levels of serum calcium might be a pothogenic and prognostic factor in colorectal cancer.

AB - Aim: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectral cancer and control patients. Methods: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these coatings, as well as the relationship between different CaSR genotypes and the data stated above. Results: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined. Conclusion: Based on these results lower levels of serum calcium might be a pothogenic and prognostic factor in colorectal cancer.

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