Relationship between retention characteristics and physicochemical parameters of solutes on a porous graphitized carbon column studied by canonical correlation analysis

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Abstract

The retention of 44 barbituric acid derivatives was determined on a porous graphitized carbon column using water-tetrahydrofuran mixtures as eluents. Good linear relationships were found between the logk' values and the organic mobile phase concentration in the eluent. The slope and intercept values of the relationship were correlated with the physicochemical parameters of the barbituric acid derivatives by means of canonical correlation analysis. The results indicate that the electronic parameters exerted the highest impact on the retention with the effect of hydrophobicity being negligible. The data indicates that the retention mechanism of a porous graphitized carbon column considerably deviates from that of traditional reversed-phase column although the eluent systems are identical.

Original languageEnglish
Pages (from-to)1867-1878
Number of pages12
JournalAnalytical Letters
Volume32
Issue number9
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • Barbituric acid derivatives
  • Canonical correlation analysis
  • Porous graphitized carbon column

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

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