Relationship between heart rate variability and endothelial function in healthy subjects

Alexandra Pinter, Tamas Horvath, Adrienn Sarkozi, M. Kollai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In various diseased states reduced cardiac vagal activity is accompanied by impaired endothelial function. Evidence from animal studies indicates interaction between the two systems, but such data from human studies is limited. The aim of this study was to test the hypothesis that cardiac vagal activity and endothelial function are related in healthy individuals.46 young males were studied. From 10. minute long ECG recordings mean RR-interval and time and frequency domain vagal heart rate variability indices (RMSSD; pNN50 and HF, respectively) were determined. Heart rate variability indices were used to define cardiac vagal activity. Endothelial function was assessed by measuring brachial artery flow mediated dilation. Hyperemic, diastolic shear rate was used to normalize flow mediated dilation.All three vagal heart rate variability indices correlated significantly and positively with flow mediated dilation across subjects, with r values within the range of 0.43-0.52, p. <0.01 for all relations. After adjusting for potential confounders, vagal heart rate variability indices remained significantly associated with normalized flow mediated dilation. RR-interval was related to most heart rate variability indices, but was not related to flow mediated dilation.Our data demonstrate that vagal heart rate variability indices are related to flow mediated dilation across healthy male subjects. The results cannot serve as evidence of a causal relationship, but are of interest and render for further investigation into underlying mechanisms.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalAutonomic Neuroscience: Basic and Clinical
Volume169
Issue number2
DOIs
Publication statusPublished - Aug 16 2012

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Dilatation
Healthy Volunteers
Heart Rate
Brachial Artery
Information Systems
Electrocardiography

Keywords

  • Cardiac vagal activity
  • Flow mediated dilation
  • Heart rate variability

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Relationship between heart rate variability and endothelial function in healthy subjects. / Pinter, Alexandra; Horvath, Tamas; Sarkozi, Adrienn; Kollai, M.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 169, No. 2, 16.08.2012, p. 107-112.

Research output: Contribution to journalArticle

Pinter, Alexandra ; Horvath, Tamas ; Sarkozi, Adrienn ; Kollai, M. / Relationship between heart rate variability and endothelial function in healthy subjects. In: Autonomic Neuroscience: Basic and Clinical. 2012 ; Vol. 169, No. 2. pp. 107-112.
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