A végrehajtó funkciók összefüggése a testtömegindexszel és a DRD4-VNTR 7-es alléllal

Translated title of the contribution: Relationship between executive functions, body mass index and the DRD4 VNTR 7-repeat allele

Julianna Bircher, Eszter Kótyuk, Renáta Cserjési, Andrea Vereczkei, Z. Rónai, M. Sasvári, A. Székely, Géza Nagy

Research output: Contribution to journalArticle

Abstract

Introduction and aim: Earlier results in the literature suggest that overweight subjects show weaker performance in executive function tasks as compared to normal weight people. Dopaminergic system is strongly linked to executive functions, body mass regulation and ingestion. The aim of the present study was to examine the possible relationship between DRD4 VNTR 7-repeat allele, body mass index and Stroop performance in a healthy adult population, and to draw psychogenetic conclusions. Method: 152 subjects without diabetic or psychiatric history participated in the study. Along with non-invasive DNA sampling, demographic, weight and height data were collected. The participants also solved the computerized Stroop task. 11 subjects belonged to the underweight (mean body mass index = 17.9 kg/m2), 98 subjects to the normal (mean body mass index = 21.8 kg/m2), and 43 subjects to the overweight (mean body mass index = 28.9 kg/m2) category. After grouping participants according to their body mass index and DRD4 VNTR genotype, we compared their mean performance to investigate the possible psychogenetic associations. Results: Body mass index and stimuli type showed significant interaction on error number (p = 0.045): subjects with normal body mass index made significantly less error as compared to under- and overweight subjects in incongruent trials. The 7-repeat allele carriers made tendentiously more errors than non-carriers. Normal weight people made less error - independently from their genotype -, while subjects with either low or high BMI carrying the 7-repeat allele made more errors compared to non-carriers. Conclusion: Under- and overweight subjects perform weaker where inhibition is necessary in the task. This may reflect their reactions to food-related situations. Orv Hetil. 2019; 160(39): 1554-1562.

Original languageHungarian
Pages (from-to)1554-1562
Number of pages9
JournalOrvosi hetilap
Volume160
Issue number39
DOIs
Publication statusPublished - Sep 1 2019

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Executive Function
Body Mass Index
Alleles
Thinness
Behavioral Genetics
Weights and Measures
Genotype
Psychiatry
Eating
Demography
Food
DNA
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A végrehajtó funkciók összefüggése a testtömegindexszel és a DRD4-VNTR 7-es alléllal. / Bircher, Julianna; Kótyuk, Eszter; Cserjési, Renáta; Vereczkei, Andrea; Rónai, Z.; Sasvári, M.; Székely, A.; Nagy, Géza.

In: Orvosi hetilap, Vol. 160, No. 39, 01.09.2019, p. 1554-1562.

Research output: Contribution to journalArticle

Bircher, Julianna ; Kótyuk, Eszter ; Cserjési, Renáta ; Vereczkei, Andrea ; Rónai, Z. ; Sasvári, M. ; Székely, A. ; Nagy, Géza. / A végrehajtó funkciók összefüggése a testtömegindexszel és a DRD4-VNTR 7-es alléllal. In: Orvosi hetilap. 2019 ; Vol. 160, No. 39. pp. 1554-1562.
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