A B típusú natriureticus peptid (NT-proBNP) szint és a diastolés funkciót jellemzo hagyományos és szöveti Doppler-echokardiográfiás paraméterek kapcsolata hypertrophiás cardiomyopathiában szenvedo betegekben

Translated title of the contribution: Relationship between B-type natriuretic peptide (NT-proBNP) levels and conventional and tissue Doppler echocardiographic parameters characterizing left ventricular diastolic function in patients with hypertrophic cardiomyopathy

Réka Faludi, Levente Tóth, László Pótó, Attila Cziráki, T. Símor, L. Papp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Preload-independent pulsed tissue Doppler echocardiography (TDI) and conventional pulsed Doppler echocardiography were used to assess the global left ventricular diastolic function in patients with hypertrophic cardiomyopathy (HCM). Levels of B-type natriuretic peptide (BNP) could be elevated in patients with isolated left ventricular diastolic dysfunction. Aim of the study was to investigate the correlation between BNP levels and the parameters measured by conventional echocardiography and TDI in patients with HCM. Patients: 32 consecutive patients with HCM (21 male, 11 female, mean age 47 ± 14 years) were studied. Inclusion criteria were: normal sinus rhythm; ejection fraction ≥ 50%; absence of moderate to severe mitral regurgitation or prosthetic mitral valve. Methods: In addition to the conventional transmitral flow patterns (E, A, E/A, DT, IVRT) myocardial early (Ea) and late diastolic (Aa) velocities were measured at the lateral and septal border of the mitral annulus by ATL HDI 5000 ultrasound system. Ea/Aa and E/Ea ratios were calculated. NT-proBNP levels were measured by Roche-Elecsys test (immunoassay). Because the distribution of BNP values did not appear to be normal, the values were transformed into a natural logarithm (InBNP). Results: Mean BNP level was 543 ± 845 pg/ml. BNP levels negatively correlated with lateral Aa values (r = -0.59, p <0.001). No significant relationship was observed between BNP levels and other echocardiographic parameters. By step-wise multiple linear regression analysis the only significant predictor of InBNP was lateral Aa value, too (r = -0.467, p <0.05). Conclusion: Significant correlation was found between BNP levels and a single TDI parameter characterizing left atrial systolic function, but there was no significant correlation between BNP levels and global left ventricular diastolic function characterized by either conventional echocardiographic or TDI parameters.

Original languageHungarian
Pages (from-to)23-26
Number of pages4
JournalOrvosi Hetilap
Volume146
Issue number1
Publication statusPublished - 2005

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Brain Natriuretic Peptide
Hypertrophic Cardiomyopathy
Left Ventricular Function
Doppler Echocardiography
Doppler Pulsed Echocardiography
Left Atrial Function
pro-brain natriuretic peptide (1-76)
Mitral Valve Insufficiency
Left Ventricular Dysfunction
Mitral Valve
Immunoassay
Echocardiography
Linear Models
Reference Values
Regression Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{0c1d6abe85104a2ca48a16ec64ec5270,
title = "A B t{\'i}pus{\'u} natriureticus peptid (NT-proBNP) szint {\'e}s a diastol{\'e}s funkci{\'o}t jellemzo hagyom{\'a}nyos {\'e}s sz{\"o}veti Doppler-echokardiogr{\'a}fi{\'a}s param{\'e}terek kapcsolata hypertrophi{\'a}s cardiomyopathi{\'a}ban szenvedo betegekben",
abstract = "Introduction: Preload-independent pulsed tissue Doppler echocardiography (TDI) and conventional pulsed Doppler echocardiography were used to assess the global left ventricular diastolic function in patients with hypertrophic cardiomyopathy (HCM). Levels of B-type natriuretic peptide (BNP) could be elevated in patients with isolated left ventricular diastolic dysfunction. Aim of the study was to investigate the correlation between BNP levels and the parameters measured by conventional echocardiography and TDI in patients with HCM. Patients: 32 consecutive patients with HCM (21 male, 11 female, mean age 47 ± 14 years) were studied. Inclusion criteria were: normal sinus rhythm; ejection fraction ≥ 50{\%}; absence of moderate to severe mitral regurgitation or prosthetic mitral valve. Methods: In addition to the conventional transmitral flow patterns (E, A, E/A, DT, IVRT) myocardial early (Ea) and late diastolic (Aa) velocities were measured at the lateral and septal border of the mitral annulus by ATL HDI 5000 ultrasound system. Ea/Aa and E/Ea ratios were calculated. NT-proBNP levels were measured by Roche-Elecsys test (immunoassay). Because the distribution of BNP values did not appear to be normal, the values were transformed into a natural logarithm (InBNP). Results: Mean BNP level was 543 ± 845 pg/ml. BNP levels negatively correlated with lateral Aa values (r = -0.59, p <0.001). No significant relationship was observed between BNP levels and other echocardiographic parameters. By step-wise multiple linear regression analysis the only significant predictor of InBNP was lateral Aa value, too (r = -0.467, p <0.05). Conclusion: Significant correlation was found between BNP levels and a single TDI parameter characterizing left atrial systolic function, but there was no significant correlation between BNP levels and global left ventricular diastolic function characterized by either conventional echocardiographic or TDI parameters.",
keywords = "Diastolic function, Hypertrophic cardiomyopathy, Natriuretic peptide",
author = "R{\'e}ka Faludi and Levente T{\'o}th and L{\'a}szl{\'o} P{\'o}t{\'o} and Attila Czir{\'a}ki and T. S{\'i}mor and L. Papp",
year = "2005",
language = "Hungarian",
volume = "146",
pages = "23--26",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "1",

}

TY - JOUR

T1 - A B típusú natriureticus peptid (NT-proBNP) szint és a diastolés funkciót jellemzo hagyományos és szöveti Doppler-echokardiográfiás paraméterek kapcsolata hypertrophiás cardiomyopathiában szenvedo betegekben

AU - Faludi, Réka

AU - Tóth, Levente

AU - Pótó, László

AU - Cziráki, Attila

AU - Símor, T.

AU - Papp, L.

PY - 2005

Y1 - 2005

N2 - Introduction: Preload-independent pulsed tissue Doppler echocardiography (TDI) and conventional pulsed Doppler echocardiography were used to assess the global left ventricular diastolic function in patients with hypertrophic cardiomyopathy (HCM). Levels of B-type natriuretic peptide (BNP) could be elevated in patients with isolated left ventricular diastolic dysfunction. Aim of the study was to investigate the correlation between BNP levels and the parameters measured by conventional echocardiography and TDI in patients with HCM. Patients: 32 consecutive patients with HCM (21 male, 11 female, mean age 47 ± 14 years) were studied. Inclusion criteria were: normal sinus rhythm; ejection fraction ≥ 50%; absence of moderate to severe mitral regurgitation or prosthetic mitral valve. Methods: In addition to the conventional transmitral flow patterns (E, A, E/A, DT, IVRT) myocardial early (Ea) and late diastolic (Aa) velocities were measured at the lateral and septal border of the mitral annulus by ATL HDI 5000 ultrasound system. Ea/Aa and E/Ea ratios were calculated. NT-proBNP levels were measured by Roche-Elecsys test (immunoassay). Because the distribution of BNP values did not appear to be normal, the values were transformed into a natural logarithm (InBNP). Results: Mean BNP level was 543 ± 845 pg/ml. BNP levels negatively correlated with lateral Aa values (r = -0.59, p <0.001). No significant relationship was observed between BNP levels and other echocardiographic parameters. By step-wise multiple linear regression analysis the only significant predictor of InBNP was lateral Aa value, too (r = -0.467, p <0.05). Conclusion: Significant correlation was found between BNP levels and a single TDI parameter characterizing left atrial systolic function, but there was no significant correlation between BNP levels and global left ventricular diastolic function characterized by either conventional echocardiographic or TDI parameters.

AB - Introduction: Preload-independent pulsed tissue Doppler echocardiography (TDI) and conventional pulsed Doppler echocardiography were used to assess the global left ventricular diastolic function in patients with hypertrophic cardiomyopathy (HCM). Levels of B-type natriuretic peptide (BNP) could be elevated in patients with isolated left ventricular diastolic dysfunction. Aim of the study was to investigate the correlation between BNP levels and the parameters measured by conventional echocardiography and TDI in patients with HCM. Patients: 32 consecutive patients with HCM (21 male, 11 female, mean age 47 ± 14 years) were studied. Inclusion criteria were: normal sinus rhythm; ejection fraction ≥ 50%; absence of moderate to severe mitral regurgitation or prosthetic mitral valve. Methods: In addition to the conventional transmitral flow patterns (E, A, E/A, DT, IVRT) myocardial early (Ea) and late diastolic (Aa) velocities were measured at the lateral and septal border of the mitral annulus by ATL HDI 5000 ultrasound system. Ea/Aa and E/Ea ratios were calculated. NT-proBNP levels were measured by Roche-Elecsys test (immunoassay). Because the distribution of BNP values did not appear to be normal, the values were transformed into a natural logarithm (InBNP). Results: Mean BNP level was 543 ± 845 pg/ml. BNP levels negatively correlated with lateral Aa values (r = -0.59, p <0.001). No significant relationship was observed between BNP levels and other echocardiographic parameters. By step-wise multiple linear regression analysis the only significant predictor of InBNP was lateral Aa value, too (r = -0.467, p <0.05). Conclusion: Significant correlation was found between BNP levels and a single TDI parameter characterizing left atrial systolic function, but there was no significant correlation between BNP levels and global left ventricular diastolic function characterized by either conventional echocardiographic or TDI parameters.

KW - Diastolic function

KW - Hypertrophic cardiomyopathy

KW - Natriuretic peptide

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