Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population

Ildikó Ungvári, Éva Hadadi, Viktor Virág, Adrienne Nagy, András Kiss, Ágnes Kalmár, Györgyi Zsigmond, Ágnes F. Semsei, András Falus, Csaba Szalai

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Air pollution and subsequent increased oxidative stress have long been recognized as contributing factors for asthma phenotypes. Individual susceptibility to oxidative stress is determined by genetic variations of the antioxidant defence system. In this study, we analysed the association between environmental nitrogen dioxide (NO2) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk. We genotyped 12 SNPs in a case-control study of 307 patients diagnosed with asthma and 344 controls. NO2 concentration was collected from the period preceding the development of asthma symptoms. Multiple logistic regression was applied to evaluate the effects of the studied genetic variations on asthma outcomes in interaction with NO2 exposure. Our data showed that genotypes of rs2588882 and rs6721961 in the regulatory regions of the NFE2L2 gene were inversely associated with infection-induced asthma (odds ratio (OR)00.290, p00.0015, and OR00.437, p0 0.007, respectively). Furthermore, case-only analyses revealed significant differences for these SNPs between asthma patients that lived in modestly or highly polluted environment (OR00.43 (0.23-0.82), p00.01, and OR0 0.51, p00.02, respectively, in a dominant model). In conclusion, our results throw some new light upon the impact of NFE2L2 polymorphisms on infection-induced asthma risk and their effect in gene-environment interactions.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalJournal of Community Genetics
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • Infection-induced asthma
  • NFE2L2
  • Nitrogen dioxide
  • Oxidative stress
  • SNP

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Genetics(clinical)

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