Relations of HL A and Rh systems to immune reactivity. Joint report of the results of 'HL A and Immune Response' Workshop, Budapest 1972

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

HL-A, ABO, and Rh antigens, as well as different kinds of humoral and cell mediated immune responses, were determined in 133 volunteers. These were selected from 463 subjects immunized with Rh(o)(D), or staphylococcus, or pertussis antigens according to their low and high immune responsiveness. Human leukocyte to locus A (HL-A) and blood group antigens were correlated by a computer program to categorized immune parameters (low, medium, high values). The latter were correlated with each other. The only notable association of the immune parameters with HL A antigens was found between HL A 3 and 7 and spontaneous lymphocytotoxic activity in mouse fibroblast monolayer. A striking correlation was, however, found between Rh antigens and a number of antibacterial antibody levels and parameters of cell mediated immune responses. These correlations indicate that Rh(o)(D) positive subjects had rather high 'natural' antibody levels and phytohemagglutinin reactive lymphocytes. The latter were stimulated, however, only with high doses of PHA (PHA hyposensitivity) and they lacked spontaneous lymphocytotoxic activity. A reverse correlation was found in Rh(o)(D) negative subjects, the ability to produce anti Rh(o)(D) antibodies being negatively associated with the level of some antibacterial antibodies. Natural antibody, immunoglobulin level and lymphocyte activity were significantly lower in males. Correlation was seldom found between categorized values of the individual immune parameters such as antibacterial antibodies, immunoglobulins, complement, and cell mediated immunity factors. Negative correlations were obtained between PHA hyposensitivity and a low antibacterial antibody level, and a positive one between IgA, complement level and lymphocyte stimulation. These results suggest that the Rh system may be associated with a gene or genes involved in immune response regulation.

Original languageEnglish
Pages (from-to)470-482
Number of pages13
JournalVox Sanguinis
Volume26
Issue number5
Publication statusPublished - 1974

Fingerprint

Immune System
Joints
Education
Antibodies
Antigens
Immunoglobulins
Lymphocytes
Whooping Cough
Phytohemagglutinins
Lymphocyte Activation
Blood Group Antigens
HLA Antigens
Staphylococcus
Cellular Immunity
Immunoglobulin A
Genes
Volunteers
Leukocytes
Software
Fibroblasts

ASJC Scopus subject areas

  • Hematology

Cite this

@article{dd0b80913d28400b831cb24a416e917d,
title = "Relations of HL A and Rh systems to immune reactivity. Joint report of the results of 'HL A and Immune Response' Workshop, Budapest 1972",
abstract = "HL-A, ABO, and Rh antigens, as well as different kinds of humoral and cell mediated immune responses, were determined in 133 volunteers. These were selected from 463 subjects immunized with Rh(o)(D), or staphylococcus, or pertussis antigens according to their low and high immune responsiveness. Human leukocyte to locus A (HL-A) and blood group antigens were correlated by a computer program to categorized immune parameters (low, medium, high values). The latter were correlated with each other. The only notable association of the immune parameters with HL A antigens was found between HL A 3 and 7 and spontaneous lymphocytotoxic activity in mouse fibroblast monolayer. A striking correlation was, however, found between Rh antigens and a number of antibacterial antibody levels and parameters of cell mediated immune responses. These correlations indicate that Rh(o)(D) positive subjects had rather high 'natural' antibody levels and phytohemagglutinin reactive lymphocytes. The latter were stimulated, however, only with high doses of PHA (PHA hyposensitivity) and they lacked spontaneous lymphocytotoxic activity. A reverse correlation was found in Rh(o)(D) negative subjects, the ability to produce anti Rh(o)(D) antibodies being negatively associated with the level of some antibacterial antibodies. Natural antibody, immunoglobulin level and lymphocyte activity were significantly lower in males. Correlation was seldom found between categorized values of the individual immune parameters such as antibacterial antibodies, immunoglobulins, complement, and cell mediated immunity factors. Negative correlations were obtained between PHA hyposensitivity and a low antibacterial antibody level, and a positive one between IgA, complement level and lymphocyte stimulation. These results suggest that the Rh system may be associated with a gene or genes involved in immune response regulation.",
author = "G. Petr{\'a}nyi and P. Ivanyi and S. Holl{\'a}n",
year = "1974",
language = "English",
volume = "26",
pages = "470--482",
journal = "Vox Sanguinis",
issn = "0042-9007",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Relations of HL A and Rh systems to immune reactivity. Joint report of the results of 'HL A and Immune Response' Workshop, Budapest 1972

AU - Petrányi, G.

AU - Ivanyi, P.

AU - Hollán, S.

PY - 1974

Y1 - 1974

N2 - HL-A, ABO, and Rh antigens, as well as different kinds of humoral and cell mediated immune responses, were determined in 133 volunteers. These were selected from 463 subjects immunized with Rh(o)(D), or staphylococcus, or pertussis antigens according to their low and high immune responsiveness. Human leukocyte to locus A (HL-A) and blood group antigens were correlated by a computer program to categorized immune parameters (low, medium, high values). The latter were correlated with each other. The only notable association of the immune parameters with HL A antigens was found between HL A 3 and 7 and spontaneous lymphocytotoxic activity in mouse fibroblast monolayer. A striking correlation was, however, found between Rh antigens and a number of antibacterial antibody levels and parameters of cell mediated immune responses. These correlations indicate that Rh(o)(D) positive subjects had rather high 'natural' antibody levels and phytohemagglutinin reactive lymphocytes. The latter were stimulated, however, only with high doses of PHA (PHA hyposensitivity) and they lacked spontaneous lymphocytotoxic activity. A reverse correlation was found in Rh(o)(D) negative subjects, the ability to produce anti Rh(o)(D) antibodies being negatively associated with the level of some antibacterial antibodies. Natural antibody, immunoglobulin level and lymphocyte activity were significantly lower in males. Correlation was seldom found between categorized values of the individual immune parameters such as antibacterial antibodies, immunoglobulins, complement, and cell mediated immunity factors. Negative correlations were obtained between PHA hyposensitivity and a low antibacterial antibody level, and a positive one between IgA, complement level and lymphocyte stimulation. These results suggest that the Rh system may be associated with a gene or genes involved in immune response regulation.

AB - HL-A, ABO, and Rh antigens, as well as different kinds of humoral and cell mediated immune responses, were determined in 133 volunteers. These were selected from 463 subjects immunized with Rh(o)(D), or staphylococcus, or pertussis antigens according to their low and high immune responsiveness. Human leukocyte to locus A (HL-A) and blood group antigens were correlated by a computer program to categorized immune parameters (low, medium, high values). The latter were correlated with each other. The only notable association of the immune parameters with HL A antigens was found between HL A 3 and 7 and spontaneous lymphocytotoxic activity in mouse fibroblast monolayer. A striking correlation was, however, found between Rh antigens and a number of antibacterial antibody levels and parameters of cell mediated immune responses. These correlations indicate that Rh(o)(D) positive subjects had rather high 'natural' antibody levels and phytohemagglutinin reactive lymphocytes. The latter were stimulated, however, only with high doses of PHA (PHA hyposensitivity) and they lacked spontaneous lymphocytotoxic activity. A reverse correlation was found in Rh(o)(D) negative subjects, the ability to produce anti Rh(o)(D) antibodies being negatively associated with the level of some antibacterial antibodies. Natural antibody, immunoglobulin level and lymphocyte activity were significantly lower in males. Correlation was seldom found between categorized values of the individual immune parameters such as antibacterial antibodies, immunoglobulins, complement, and cell mediated immunity factors. Negative correlations were obtained between PHA hyposensitivity and a low antibacterial antibody level, and a positive one between IgA, complement level and lymphocyte stimulation. These results suggest that the Rh system may be associated with a gene or genes involved in immune response regulation.

UR - http://www.scopus.com/inward/record.url?scp=0016153726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016153726&partnerID=8YFLogxK

M3 - Article

C2 - 4210390

AN - SCOPUS:0016153726

VL - 26

SP - 470

EP - 482

JO - Vox Sanguinis

JF - Vox Sanguinis

SN - 0042-9007

IS - 5

ER -