Relation of the IGF/IGF1R system to autophagy in colitis and colorectal cancer

Ferenc Sipos, Hajnal Székely, Imre Dániel Kis, Zsolt Tulassay, Györgyi Muzes

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Metabolic syndrome (MetS), as a chronic inflammatory disorder has a potential role in the development of inflammatory and cancerous complications of the colonic tissue. The interaction of DNA damage and inflammation is affected by the insulin-like growth factor 1 receptor (IGF1R) signaling pathway. The IGF1R pathway has been reported to regulate autophagy, as well, but sometimes through a bidirectional context. Targeting the IGF1R-Autophagy crosstalk could represent a promising strategy for the development of new antiinflammatory and anticancer therapies, and may help for subjects suffering from MetS who are at increased risk of colorectal cancer. However, therapeutic responses to targeted therapies are often shortlived, since a signaling crosstalk of IGF1R with other receptor tyrosine kinases or autophagy exists, leading to acquired cellular resistance to therapy. From a pharmacological point of view, it is attractive to speculate that synergistic benefits could be achieved by inhibition of one of the key effectors of the IGF1R pathway, in parallel with the pharmacological stimulation of the autophagy machinery, but cautiousness is also required, because pharmacologic IGF1R modulation can initiate additional, sometimes unfavorable biologic effects.

Original languageEnglish
Pages (from-to)8109-8119
Number of pages11
JournalWorld journal of gastroenterology
Volume23
Issue number46
DOIs
Publication statusPublished - Dec 14 2017

Keywords

  • Autophagy
  • Colitis
  • Colorectal cancer
  • IGF1R
  • Insulin-like growth factor
  • Metabolic syndrome

ASJC Scopus subject areas

  • Gastroenterology

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