Relation of renal thromboxane A2 production to urine flow, electrolyte excretion and plasma renin activity in control state and drug induced hypotension

B. Székács, E. Mohácsi, B. Gachályi, K. Tihanyi, I. Juhász

Research output: Contribution to journalArticle

Abstract

The functional importance of renal TxB2 generation in the maintenance of elevated arterial blood pressure in essential hypertension was followed in 22 patients, using the method of sustained blood pressure decrease by i.v. sodium nitroprusside infusion. Linear correlation between urinary excretion of TxB2, urine flow, and sodium excretion could be established in both control and hypotensive periods. Presumably, changes in urinary excretion of TxB2 reflect a secondary intrarenal counterregulatory response.

Original languageEnglish
Pages (from-to)183-191
Number of pages9
JournalInternational urology and nephrology
Volume20
Issue number2
DOIs
Publication statusPublished - Mar 1 1988

ASJC Scopus subject areas

  • Nephrology
  • Urology

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