Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients

Katalin Koltai, G. Fehér, Peter Kenyeres, Imre Lenart, Tamas Alexy, B. Horváth, Zsolt Marton, Gabor Kesmarky, K. Tóth

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In our present study we investigated the association between platelet aggregation in patients treated with the most widely used antiplatelet agents (100 and 300-325 mg acetylsalicylic acid (ASA), 75 mg clopidogrel, 500 mg ticlopidine and the combination of 100 mg aspirin and 75 mg clopidogrel), fibrinogen levels and aging. Between 2001 and 2005 we measured in vitro platelet aggregation in 5026 vascular patients according to the method of Born. Platelet aggregation was tested with 5 and 10 μM adenosine-diphosphate, 2 μg/ml collagen and 10 μM epinephrine stimulants. Fibrinogen level was simultaneously measured in a subgroup of 3243 patients. The subjects were divided by age into decades. Platelet aggregation increased significantly with advancing age in the case of 100 and 300-325 mg ASA-treated patients (p

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalClinical Hemorheology and Microcirculation
Volume40
Issue number4
DOIs
Publication statusPublished - 2008

Fingerprint

clopidogrel
Platelet Aggregation
Fibrinogen
Aspirin
Ticlopidine
Platelet Aggregation Inhibitors
Adenosine Diphosphate
Epinephrine
Blood Vessels
Collagen
thienopyridine

Keywords

  • Aging
  • Aspirin
  • Clopidogrel
  • Fibrinogen
  • Platelet aggregation
  • Ticlopidine

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. / Koltai, Katalin; Fehér, G.; Kenyeres, Peter; Lenart, Imre; Alexy, Tamas; Horváth, B.; Marton, Zsolt; Kesmarky, Gabor; Tóth, K.

In: Clinical Hemorheology and Microcirculation, Vol. 40, No. 4, 2008, p. 295-302.

Research output: Contribution to journalArticle

Koltai, Katalin ; Fehér, G. ; Kenyeres, Peter ; Lenart, Imre ; Alexy, Tamas ; Horváth, B. ; Marton, Zsolt ; Kesmarky, Gabor ; Tóth, K. / Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients. In: Clinical Hemorheology and Microcirculation. 2008 ; Vol. 40, No. 4. pp. 295-302.
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