Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans

Istvan Bonyhay, Gabor Jokkel, M. Kollai

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

We investigated whether physiological variability in arterial baroreflex sensitivity (BRS) was related to differences in carotid elastic behavior among 19 young healthy subjects (age 18-26 yr). The diameter of the carotid artery (D) and its change during the arterial pulse (ΔD) were monitored by a phase-locked echotracking device (UT-4 Hokanson), and pulse pressure (ΔP) was measured in the brachial artery by sphygmomanometry. Distensibility coefficient (DC) for the common carotid artery was calculated using the formula DC = (2 × ΔD/D)/ΔP. Dynamic elastic parameters such as the maximum and mean rate of carotid artery expansion and the dominant harmonic frequency of the diameter curve were also determined. BRS was assessed by regressing R-R intervals against systolic blood pressure, monitored by finger arterial pressure (FINAPRES), during an elevation of pressure, induced by intravenous bolus injection of phenylephrine. Using correlation and stepwise regression analysis, we found that BRS was significantly related to carotid artery distensibility (r = 0.778, P <0.001) but was not related to any of the dynamic parameters of carotid pulsation.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume40
Issue number3
Publication statusPublished - Sep 1996

Fingerprint

Baroreflex
Elasticity
Carotid Arteries
Blood Pressure
Brachial Artery
Common Carotid Artery
Phenylephrine
Intravenous Injections
Fingers
Pulse
Healthy Volunteers
Arterial Pressure
Regression Analysis
Pressure
Equipment and Supplies

Keywords

  • Distensibility coefficient
  • Dominant harmonic frequency

ASJC Scopus subject areas

  • Physiology

Cite this

Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans. / Bonyhay, Istvan; Jokkel, Gabor; Kollai, M.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 40, No. 3, 09.1996.

Research output: Contribution to journalArticle

@article{a978fd7d05a4465fbc0303f0ce1f43c4,
title = "Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans",
abstract = "We investigated whether physiological variability in arterial baroreflex sensitivity (BRS) was related to differences in carotid elastic behavior among 19 young healthy subjects (age 18-26 yr). The diameter of the carotid artery (D) and its change during the arterial pulse (ΔD) were monitored by a phase-locked echotracking device (UT-4 Hokanson), and pulse pressure (ΔP) was measured in the brachial artery by sphygmomanometry. Distensibility coefficient (DC) for the common carotid artery was calculated using the formula DC = (2 × ΔD/D)/ΔP. Dynamic elastic parameters such as the maximum and mean rate of carotid artery expansion and the dominant harmonic frequency of the diameter curve were also determined. BRS was assessed by regressing R-R intervals against systolic blood pressure, monitored by finger arterial pressure (FINAPRES), during an elevation of pressure, induced by intravenous bolus injection of phenylephrine. Using correlation and stepwise regression analysis, we found that BRS was significantly related to carotid artery distensibility (r = 0.778, P <0.001) but was not related to any of the dynamic parameters of carotid pulsation.",
keywords = "Distensibility coefficient, Dominant harmonic frequency",
author = "Istvan Bonyhay and Gabor Jokkel and M. Kollai",
year = "1996",
month = "9",
language = "English",
volume = "40",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Relation between baroreflex sensitivity and carotid artery elasticity in healthy humans

AU - Bonyhay, Istvan

AU - Jokkel, Gabor

AU - Kollai, M.

PY - 1996/9

Y1 - 1996/9

N2 - We investigated whether physiological variability in arterial baroreflex sensitivity (BRS) was related to differences in carotid elastic behavior among 19 young healthy subjects (age 18-26 yr). The diameter of the carotid artery (D) and its change during the arterial pulse (ΔD) were monitored by a phase-locked echotracking device (UT-4 Hokanson), and pulse pressure (ΔP) was measured in the brachial artery by sphygmomanometry. Distensibility coefficient (DC) for the common carotid artery was calculated using the formula DC = (2 × ΔD/D)/ΔP. Dynamic elastic parameters such as the maximum and mean rate of carotid artery expansion and the dominant harmonic frequency of the diameter curve were also determined. BRS was assessed by regressing R-R intervals against systolic blood pressure, monitored by finger arterial pressure (FINAPRES), during an elevation of pressure, induced by intravenous bolus injection of phenylephrine. Using correlation and stepwise regression analysis, we found that BRS was significantly related to carotid artery distensibility (r = 0.778, P <0.001) but was not related to any of the dynamic parameters of carotid pulsation.

AB - We investigated whether physiological variability in arterial baroreflex sensitivity (BRS) was related to differences in carotid elastic behavior among 19 young healthy subjects (age 18-26 yr). The diameter of the carotid artery (D) and its change during the arterial pulse (ΔD) were monitored by a phase-locked echotracking device (UT-4 Hokanson), and pulse pressure (ΔP) was measured in the brachial artery by sphygmomanometry. Distensibility coefficient (DC) for the common carotid artery was calculated using the formula DC = (2 × ΔD/D)/ΔP. Dynamic elastic parameters such as the maximum and mean rate of carotid artery expansion and the dominant harmonic frequency of the diameter curve were also determined. BRS was assessed by regressing R-R intervals against systolic blood pressure, monitored by finger arterial pressure (FINAPRES), during an elevation of pressure, induced by intravenous bolus injection of phenylephrine. Using correlation and stepwise regression analysis, we found that BRS was significantly related to carotid artery distensibility (r = 0.778, P <0.001) but was not related to any of the dynamic parameters of carotid pulsation.

KW - Distensibility coefficient

KW - Dominant harmonic frequency

UR - http://www.scopus.com/inward/record.url?scp=33750741480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750741480&partnerID=8YFLogxK

M3 - Article

C2 - 8853352

AN - SCOPUS:33750741480

VL - 40

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 3

ER -