Relation between baroreflex sensitivity and cardiac vagal tone in humans

M. Kollai, G. Jokkel, I. Bonyhay, J. Tomcsanyi, A. Naszlady

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The extent of dependence of cardiac vagal tone on arterial baroreceptor input has been studied in 12 healthy, young adult subjects. Cardiac vagal tone was defined as the change in R-R interval after complete cholinergic blockade by atropine. Baroreflex sensitivity was determined with the 'Oxford- method': R-R interval was regressed against systolic pressure. The interindividual correlation between cardiac vagal tone and baroreflex sensitivity for falling pressures was found to be significant, but not close (R = 0.81, P = 0.002). In each subject, the baroreflex regression line for falling pressures was extrapolated to the postatropine R-R interval level; 50 mmHg was considered as minimum and 80 mmHg as maximum threshold level for the integrated baroreflex. From the relation between the individual regression lines and the minimum and maximum threshold levels, it was concluded that cardiac vagal tone could be generated by both baroreflex-dependent and - independent mechanisms, the ratio of which varies in different individuals, with the baroreflex-dependent mechanism being the dominant factor.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume266
Issue number1 35-1
Publication statusPublished - 1994

Fingerprint

Baroreflex
Accidental Falls
cholinergic agents
atropine
young adults
Pressure
Pressoreceptors
Atropine
Cholinergic Agents
Young Adult
Blood Pressure
methodology

Keywords

  • arterial baroreceptors
  • atropine
  • autonomic
  • baroreflex threshold
  • heart
  • nitroglycerin

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Relation between baroreflex sensitivity and cardiac vagal tone in humans. / Kollai, M.; Jokkel, G.; Bonyhay, I.; Tomcsanyi, J.; Naszlady, A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 266, No. 1 35-1, 1994.

Research output: Contribution to journalArticle

@article{23c37f6a321842bc9bb248fdd5b7e1cc,
title = "Relation between baroreflex sensitivity and cardiac vagal tone in humans",
abstract = "The extent of dependence of cardiac vagal tone on arterial baroreceptor input has been studied in 12 healthy, young adult subjects. Cardiac vagal tone was defined as the change in R-R interval after complete cholinergic blockade by atropine. Baroreflex sensitivity was determined with the 'Oxford- method': R-R interval was regressed against systolic pressure. The interindividual correlation between cardiac vagal tone and baroreflex sensitivity for falling pressures was found to be significant, but not close (R = 0.81, P = 0.002). In each subject, the baroreflex regression line for falling pressures was extrapolated to the postatropine R-R interval level; 50 mmHg was considered as minimum and 80 mmHg as maximum threshold level for the integrated baroreflex. From the relation between the individual regression lines and the minimum and maximum threshold levels, it was concluded that cardiac vagal tone could be generated by both baroreflex-dependent and - independent mechanisms, the ratio of which varies in different individuals, with the baroreflex-dependent mechanism being the dominant factor.",
keywords = "arterial baroreceptors, atropine, autonomic, baroreflex threshold, heart, nitroglycerin",
author = "M. Kollai and G. Jokkel and I. Bonyhay and J. Tomcsanyi and A. Naszlady",
year = "1994",
language = "English",
volume = "266",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "1 35-1",

}

TY - JOUR

T1 - Relation between baroreflex sensitivity and cardiac vagal tone in humans

AU - Kollai, M.

AU - Jokkel, G.

AU - Bonyhay, I.

AU - Tomcsanyi, J.

AU - Naszlady, A.

PY - 1994

Y1 - 1994

N2 - The extent of dependence of cardiac vagal tone on arterial baroreceptor input has been studied in 12 healthy, young adult subjects. Cardiac vagal tone was defined as the change in R-R interval after complete cholinergic blockade by atropine. Baroreflex sensitivity was determined with the 'Oxford- method': R-R interval was regressed against systolic pressure. The interindividual correlation between cardiac vagal tone and baroreflex sensitivity for falling pressures was found to be significant, but not close (R = 0.81, P = 0.002). In each subject, the baroreflex regression line for falling pressures was extrapolated to the postatropine R-R interval level; 50 mmHg was considered as minimum and 80 mmHg as maximum threshold level for the integrated baroreflex. From the relation between the individual regression lines and the minimum and maximum threshold levels, it was concluded that cardiac vagal tone could be generated by both baroreflex-dependent and - independent mechanisms, the ratio of which varies in different individuals, with the baroreflex-dependent mechanism being the dominant factor.

AB - The extent of dependence of cardiac vagal tone on arterial baroreceptor input has been studied in 12 healthy, young adult subjects. Cardiac vagal tone was defined as the change in R-R interval after complete cholinergic blockade by atropine. Baroreflex sensitivity was determined with the 'Oxford- method': R-R interval was regressed against systolic pressure. The interindividual correlation between cardiac vagal tone and baroreflex sensitivity for falling pressures was found to be significant, but not close (R = 0.81, P = 0.002). In each subject, the baroreflex regression line for falling pressures was extrapolated to the postatropine R-R interval level; 50 mmHg was considered as minimum and 80 mmHg as maximum threshold level for the integrated baroreflex. From the relation between the individual regression lines and the minimum and maximum threshold levels, it was concluded that cardiac vagal tone could be generated by both baroreflex-dependent and - independent mechanisms, the ratio of which varies in different individuals, with the baroreflex-dependent mechanism being the dominant factor.

KW - arterial baroreceptors

KW - atropine

KW - autonomic

KW - baroreflex threshold

KW - heart

KW - nitroglycerin

UR - http://www.scopus.com/inward/record.url?scp=0027953029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027953029&partnerID=8YFLogxK

M3 - Article

VL - 266

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 1 35-1

ER -