Relapsing polychondritis

Peter Gergely, G. Poór

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Relapsing polychondritis (RP) is a rare multisystem autoimmune disease of unknown origin characterized by recurrent episodes of inflammation and progressive destruction of cartilaginous tissues. Elastic cartilage of the ears and nose, hyaline cartilage of peripheral joints, vertebral fibrocartilage and tracheobronchial cartilage, as well as proteoglycan-rich structures of the eye, heart, blood vessels or inner ear may all be affected. In most patients RP manifests in a fluctuating but progressive course which eventually results in a significant shortening of life expectancy. The relatively uncommon occurrence, the unknown etiopathogenesis, the ambiguous clinical pattern, as well as the variety in its course and response to therapy may all contribute to the difficulties the physician must overcome when managing RP. Beside describing the main features of RP and seven clinical cases of our own, in the present review we focus on recent findings in the etiopathogenesis and novel treatment options.

Original languageEnglish
Pages (from-to)723-738
Number of pages16
JournalBest Practice and Research: Clinical Rheumatology
Volume18
Issue number5 SPEC. ISS.
DOIs
Publication statusPublished - Oct 2004

Fingerprint

Relapsing Polychondritis
Elastic Cartilage
Fibrocartilage
Hyaline Cartilage
Inner Ear
Proteoglycans
Life Expectancy
Nose
Autoimmune Diseases
Cartilage
Ear
Blood Vessels
Joints
Inflammation
Physicians
Therapeutics

Keywords

  • Biological therapy
  • Etiopathogenesis
  • Relapsing polychondritis
  • Review

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Relapsing polychondritis. / Gergely, Peter; Poór, G.

In: Best Practice and Research: Clinical Rheumatology, Vol. 18, No. 5 SPEC. ISS., 10.2004, p. 723-738.

Research output: Contribution to journalArticle

Gergely, Peter ; Poór, G. / Relapsing polychondritis. In: Best Practice and Research: Clinical Rheumatology. 2004 ; Vol. 18, No. 5 SPEC. ISS. pp. 723-738.
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