Regulatórikus T-sejtek a terhességi immuntolerancia fenntartásában

Translated title of the contribution: Regulatory T cells in the maintenance of immunotolerance during pregnancy

Kiss Attila András, Pap Erna, A. Falus, Török Miklós, E. Pállinger

Research output: Contribution to journalArticle

Abstract

Maternal immunotolerance induced by fetal antigens is essential for the embryogenesis and for the maintenance of the gestation. Regulatory T cells have a major role in the induction of tolerance during pregnancy. Tregs display their effector functions by their capacity to suppress cytotoxic T cells and by their production of regulatory cytokines. On the basis of animal experiments, the diminished number or function of regulatory T cells can cause pregnancy loss, but it can be prevented by the transfer of Tregs prior to exposure to paternal alloantigens. Understanding the role of Tregs in the fetomaternal tolerance has important implications in the recognition of immunopathomechanisms of pathological pregnancies and also in developing novel strategies to induce immune tolerance in order to prevent miscarriages.

Original languageHungarian
Pages (from-to)283-288
Number of pages6
JournalMagyar Noorvosok Lapja
Volume72
Issue number6
Publication statusPublished - 2009

Fingerprint

Regulatory T-Lymphocytes
Maintenance
Pregnancy
Paternal Exposure
Immune Tolerance
Isoantigens
Spontaneous Abortion
Embryonic Development
Mothers
Cytokines
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Regulatórikus T-sejtek a terhességi immuntolerancia fenntartásában. / András, Kiss Attila; Erna, Pap; Falus, A.; Miklós, Török; Pállinger, E.

In: Magyar Noorvosok Lapja, Vol. 72, No. 6, 2009, p. 283-288.

Research output: Contribution to journalArticle

András, Kiss Attila ; Erna, Pap ; Falus, A. ; Miklós, Török ; Pállinger, E. / Regulatórikus T-sejtek a terhességi immuntolerancia fenntartásában. In: Magyar Noorvosok Lapja. 2009 ; Vol. 72, No. 6. pp. 283-288.
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