Maternal immunotolerance induced by fetal antigens is essential for the embryogenesis and for the maintenance of the gestation. Regulatory T cells have a major role in the induction of tolerance during pregnancy. Tregs display their effector functions by their capacity to suppress cytotoxic T cells and by their production of regulatory cytokines. On the basis of animal experiments, the diminished number or function of regulatory T cells can cause pregnancy loss, but it can be prevented by the transfer of Tregs prior to exposure to paternal alloantigens. Understanding the role of Tregs in the fetomaternal tolerance has important implications in the recognition of immunopathomechanisms of pathological pregnancies and also in developing novel strategies to induce immune tolerance in order to prevent miscarriages.
|Translated title of the contribution||Regulatory T cells in the maintenance of immunotolerance during pregnancy|
|Number of pages||6|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Dec 1 2009|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology