Cerebellar granule neurons express GABAA and GABAB both of which can be induced by exposure of the cells to GABA or GABAA receptor agonists. Both types of receptors mediate an inhibitory action on transmitter release and the GABAB receptors are coupled negatively to regulation of depolarization induced increase in [Ca++]1. Inducible GABAB receptors show an atypical coupling to G-proteins. A coupling of the GABAA and GABAB receptors seems to exist with regard to regulation of transmitter release.
|Number of pages||3|
|Journal||Pharmacology Reviews and Communications|
|Publication status||Published - Dec 1 1996|
- GABA- and GABA-receptors
ASJC Scopus subject areas