Regulatory role of GABAA and GABAB receptors in Ca++ homeostasis and transmitter release in cerebellar granule neurons

Arne Schousboe, Julianna Kardos

Research output: Contribution to journalArticle

Abstract

Cerebellar granule neurons express GABAA and GABAB both of which can be induced by exposure of the cells to GABA or GABAA receptor agonists. Both types of receptors mediate an inhibitory action on transmitter release and the GABAB receptors are coupled negatively to regulation of depolarization induced increase in [Ca++]1. Inducible GABAB receptors show an atypical coupling to G-proteins. A coupling of the GABAA and GABAB receptors seems to exist with regard to regulation of transmitter release.

Original languageEnglish
Pages (from-to)235-237
Number of pages3
JournalPharmacology Reviews and Communications
Volume8
Issue number2-3
Publication statusPublished - Dec 1 1996

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Keywords

  • Calcium
  • G-proteins
  • GABA- and GABA-receptors
  • Glutamate
  • Neurons
  • Neurotransmission

ASJC Scopus subject areas

  • Pharmacology

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