Regulatory immune cells and functions in autoimmunity and transplantation immunology

Gabor Papp, Peter Boros, Britt Nakken, Peter Szodoray, Margit Zeher

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

In physiological circumstances, various tolerogenic mechanisms support the protection of self-structures during immune responses. However, quantitative and/or qualitative changes in regulatory immune cells and mediators can evoke auto-reactive immune responses, and upon susceptible genetic background, along with the presence of other concomitant etiological factors, autoimmune disease may develop. In transplant immunology, tolerogenic mechanisms are also critical, since the balance between of alloantigen-reactive effector cells and the regulatory immune cells will ultimately determine whether a graft is accepted or rejected. Better understanding of the immunological tolerance and the potential modulations of immune regulatory processes are crucial for developing effective therapies in autoimmune diseases as well as in organ transplantation. In this review, we focus on the novel insights regarding the impaired immune regulation and other relevant factors contributing to the development of auto-reactive and graft-reactive immune responses in autoimmune diseases and transplant rejection, respectively. We also address some promising approaches for modification of immune-regulatory processes and tolerogenic mechanisms in autoimmunity and solid organ transplantation, which may be beneficial in future therapeutic strategies.

Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalAutoimmunity Reviews
Volume16
Issue number5
DOIs
Publication statusPublished - May 2017

Keywords

  • Autoimmunity
  • Regulatory cells
  • Systemic autoimmune diseases
  • Tolerance induction
  • Transplant rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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