Regulatory function of cell surface molecules CD2-, LFA- and β2-microglobulin in natural killer cell activity

G. Gy Petrányi, Eva Pócsik, Beatrice Kotlán, Gy Görög, M. Benczur

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The functional importance of various cell membrane bound molecules was studied and compared in the NK cytotoxicity and CTL activity. LFA-1 and CD2 participate in both killing functions, while CD3 and CD8/CD4 as well as MHC class I molecules are involved only in CTL activity. Nevertheless CD2- and β2-microglobulin are representatives of the NK function. It was demonstrated that CD2-, LFA-1 and β2-microglobulin molecules have an additive and complementary function in the killing mechanism. The upregulation of α- and γ-interferons on NK function seems not to be a consequence of the enhanced expression of these molecules on the cell surface induced by IF at the same time.

Original languageEnglish
Pages (from-to)1275-1279
Number of pages5
JournalMolecular Immunology
Volume23
Issue number11
DOIs
Publication statusPublished - Nov 1986

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ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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