Regulation of transendothelial transport in the cerebral microvessels: The role of second messengers-generating systems

F. Joó, I. Lengyel, J. Kovács, B. Penke

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Different elements of the intracellular signaling messenger systems have been detected in the course of our studies in the cerebral endothelial cells. It has been shown that the synthesizing enzymes of and substrate proteins for the second messenger molecules are present in the cerebral endothelial cells, and their activity and/or amount can change in pathological circumstances, i.e., during the formation of brain oedema. Pharmacological treatments interfering with the second messenger systems proved to be effective in the prevention of brain oedema formation.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalProgress in Brain Research
Volume91
Issue numberC
DOIs
Publication statusPublished - Jan 1 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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