Regulation of specific activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in Penicillium chrysogenum

T. Emri, G. Bartók, A. Szentirmai

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The specific activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase changed when Penicillium chrysogenum was grown on different carbon sources. In the presence of 2% lactose, the activities of these enzymes were approximately 25-35% lower than those in media containing 2% glucose or 2% fructose. We assume that an increase in cAMP concentration was responsible for the observed decreases in the enzyme activities, because a higher cAMP concentration could be detected when the mycelium was grown in a medium containing solely lactose as carbon source. The likely role played by cAMP in the regulation was also demonstrated by the addition of either cAMP or caffeine to the medium.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalFEMS microbiology letters
Volume117
Issue number1
DOIs
Publication statusPublished - Mar 15 1994

Keywords

  • 6-Phosphogluconate dehydrogenase
  • Glucose-6-phosphate dehydrogenase
  • Penicillium chrysogenum
  • cAMP

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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