Regulation of purinoceptors in guinea pig pulmonary artery: Functional evidences

A. J. Szentmiklósi, A. Ujfalusi, Á Cseppento, K. Antal, P. Kovács, J. Zs Szabó

Research output: Contribution to journalArticle

Abstract

In isolated guinea pig pulmonary arteries (precontracted with 1 μM noradrenaline) N6-cyclopentyladenosine (CPA), a selective A1 adenosine receptor agonist, exerted a concentration-dependent contraction, whereas 5′-N-ethylcarboxamidoadenosine (NECA), a non-selective A1/A2 receptor agonist, in the presence of DPCPX (a highly selective A1 receptor antagonist), produced a concentration-related rapid relaxation. Pulmonary arteries obtained from guinea pigs treated with aminophylline (APH) or 8-phenyltheophylline (8-PT) for 10 consecutive days, displayed more pronounced contraction in response to CPA compared to those of solvent-treated animals. Relaxant action of NECA was, however, attenuated in arteries prepared from methylxanthine-treated guinea pigs. Opposite changes were found in vascular tissues excised from chronically dipyridamole(DP)-treated guinea pigs.

Original languageEnglish
Pages (from-to)339-341
Number of pages3
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Keywords

  • Methylxanthines
  • Pulmonary artery
  • Regulation of adenosine receptors

ASJC Scopus subject areas

  • Physiology (medical)

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    Szentmiklósi, A. J., Ujfalusi, A., Cseppento, Á., Antal, K., Kovács, P., & Szabó, J. Z. (1996). Regulation of purinoceptors in guinea pig pulmonary artery: Functional evidences. Acta physiologica Hungarica, 84(3), 339-341.