Regulation of neutrophil functions and signaling by vitamin E compounds

Zsuzsa Varga, Francesco Galli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Reactive-oxygen-species (ROS) indispenseble for life but they also have harmful properties inducing ROS-mediated diseases. They are produced by several cells, among them neutrophils and neutrophils can contribute to oxidative modification of lipids and proteins in circulation. As summarized here, during the last decades, several experiments showed that vitamin E (α-tocopherol) and related compounds (e.g. hypomethylated tocopherols and 2,2'-carboxyethyl-hydroxychromans, water soluble metabolites, CEHCs) can modify neutrophil functions playing role in host defence such as migration of cells to place of inflammation, phagocytosis, ROS production, protein kinase C (PKC), cyclooxygenase 2 (COX2) and other inflammatory enzyme activities. Intriguingly, in some of these regulatory events hypomethylated compounds - especially γ-tocopherol and γ-CEHC - were found to be more effective than α-tocopherol suggesting close structural specificity in these mechanisms.This review paper examines the literature on these aspects and the pathobiological relevance of vitamin E in the regulation of neutrophil function.

Original languageEnglish
Title of host publicationTocopherol
Subtitle of host publicationSources, Uses and Health Benefits
PublisherNova Science Publishers, Inc.
Pages233-255
Number of pages23
ISBN (Print)9781621007043
Publication statusPublished - Dec 1 2012

Keywords

  • CEHCs
  • NADPH oxidase
  • Neutrophils
  • Oxidative stress
  • PKC
  • Tocopherols

ASJC Scopus subject areas

  • Medicine(all)

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    Varga, Z., & Galli, F. (2012). Regulation of neutrophil functions and signaling by vitamin E compounds. In Tocopherol: Sources, Uses and Health Benefits (pp. 233-255). Nova Science Publishers, Inc..