Regulation of mast cell activation by complement-derived peptides

A. Erdei, Márton Andrásfalvy, Hajna Péterfy, G. Tóth, Israel Pecht

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

It is known for more than 25 years that the complement-derived anaphylatoxic peptides, C3a, C4a and C5a are potent activators of basophils and certain types of mast cells. Although tissue distribution of receptors for C3a and C5a well exceeds myeloid cells, apparently they are not expressed on mucosal type mast cells, consequently these cells are not activated by C3a and C5a. Our results do however demonstrate that C3a and peptides related to this complement activation product are able to inhibit FcεRI-clustering induced activation of mucosal type mast cells - such as RBL-2H3 cells and bone-marrow derived mast cells. Based on the current results we propose the presence of separate "activator" and "inhibitor" sequence motifs in C3a which are in balance under physiologic conditions.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalImmunology Letters
Volume92
Issue number1-2
DOIs
Publication statusPublished - Mar 29 2004

Fingerprint

Complement Activation
Mast Cells
Peptides
Anaphylatoxin C5a Receptor
Basophils
Myeloid Cells
Tissue Distribution
Bone Marrow Cells
Cluster Analysis

Keywords

  • Activation
  • Anaphylatoxic peptides
  • C3a
  • C5a
  • Inhibition
  • Serosal and mucosal type mast cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Regulation of mast cell activation by complement-derived peptides. / Erdei, A.; Andrásfalvy, Márton; Péterfy, Hajna; Tóth, G.; Pecht, Israel.

In: Immunology Letters, Vol. 92, No. 1-2, 29.03.2004, p. 39-42.

Research output: Contribution to journalArticle

Erdei, A. ; Andrásfalvy, Márton ; Péterfy, Hajna ; Tóth, G. ; Pecht, Israel. / Regulation of mast cell activation by complement-derived peptides. In: Immunology Letters. 2004 ; Vol. 92, No. 1-2. pp. 39-42.
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