Regulation of macrophage inflammatory protein-1α expression and function by endogenous interleukin-10 in a model of acute inflammation

Maureen N. Ajuebor, Anuk M. Das, László Virág, Csaba Szabó, Mauro Perretti

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

In this study we have determined the role of endogenous interleukin (IL)-10 on leucocyte recruitment and production of the CC chemokine macrophage inflammatory protein-1α (MIP-1α) in a murine model of acute inflammation. Intraperitoneal injection of zymosan produced a dose-dependent cellular infiltration which was concomitant with MIP-1α release in the lavage fluids. Release of this chemokine had a functional role since treatment of mice with a specific anti-MIP-1α antibody reduced both neutrophil and monocyte accumulation into the peritoneal cavity. An unexpected increase in cell influx and MIP-1α production was measured following depletion of resident peritoneal macrophages, as achieved by a 3-day liposome treatment. A similar result was obtained when the zymosan peritonitis response was elicited in IL-10 knock-out mice. In summary we propose a functional cross talk between endogenous IL-10 and this CC chemokine during the host inflammatory response.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalBiochemical and biophysical research communications
Volume255
Issue number2
DOIs
Publication statusPublished - Feb 16 1999

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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