Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes

Joachim Bauer, G. Lengyel, Tilman Martin Bauer, George Acs, Wolfgang Gerok

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Human blood monocytes normally express the interleukin-6 receptor. Treatment of cultured monocytes with endotoxin, interleukin-1β, or interleukin-6 results in a decrease of interleukin-6 receptor mRNA levels. Glucocorticoids also cause a drop in monocytic interleukin-6 receptor mRNA levels. We also found interleukin-6 receptor expression in cultured human hepatocytes, but in contrast to monocytes, where interleukin-6 receptor mRNA is repressed by the ligand and by interleukin-1, treatment of hepatocytes with interleukin-6 or interleukin-1 resulted in increased interleukin-6 receptor mRNA levels. Induction of interleukin-6 receptor mRNA in hepatocytes was less pronounced when glucocorticoids were omitted from the culture medium. We conclude that during noninflammatory homeostasis, blood monocytes are involved in binding of trace amounts of circulating interleukin-6. During inflammatory events, the main tissue target of interleukin-6 may be changed from the monocytic population not only to activated B-cells, but also to the hepatocytes.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalFEBS Letters
Volume249
Issue number1
DOIs
Publication statusPublished - May 22 1989

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Interleukin-6 Receptors
Monocytes
Hepatocytes
Interleukin-6
Messenger RNA
Interleukin-1
Glucocorticoids
Blood
Endotoxins
Culture Media
Homeostasis
B-Lymphocytes
Cells
Tissue
Ligands

Keywords

  • Hepatocyte
  • Inflammation
  • Interleukin-6
  • Monocyte
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes. / Bauer, Joachim; Lengyel, G.; Bauer, Tilman Martin; Acs, George; Gerok, Wolfgang.

In: FEBS Letters, Vol. 249, No. 1, 22.05.1989, p. 27-30.

Research output: Contribution to journalArticle

Bauer, Joachim ; Lengyel, G. ; Bauer, Tilman Martin ; Acs, George ; Gerok, Wolfgang. / Regulation of interleukin-6 receptor expression in human monocytes and hepatocytes. In: FEBS Letters. 1989 ; Vol. 249, No. 1. pp. 27-30.
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