Regulation of inflammation by adenosine

G. Haskó, Bruce Cronstein

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its receptors as feedback regulators of inflammation has been well established. Here we review the effects of adenosine, acting at its receptors, on neutrophil and monocyte/macrophage function in inflammation. Moreover, we review the role of adenosine in mediating the anti-inflammatory effects of methotrexate, the anchor drug in the treatment of Rheumatoid Arthritis and other inflammatory disorders.

Original languageEnglish
Article numberArticle 85
JournalFrontiers in Immunology
Volume4
Issue numberAPR
DOIs
Publication statusPublished - 2013

Fingerprint

Adenosine
Inflammation
Neutrophils
Purine Nucleosides
Purinergic P1 Receptors
Adenine Nucleotides
Methotrexate
Monocytes
Rheumatoid Arthritis
Anti-Inflammatory Agents
Macrophages
Pharmaceutical Preparations

Keywords

  • Adenosine
  • Adenosine receptors
  • Macrophages
  • Monocytes
  • Neutrophils

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Regulation of inflammation by adenosine. / Haskó, G.; Cronstein, Bruce.

In: Frontiers in Immunology, Vol. 4, No. APR, Article 85, 2013.

Research output: Contribution to journalArticle

Haskó, G. ; Cronstein, Bruce. / Regulation of inflammation by adenosine. In: Frontiers in Immunology. 2013 ; Vol. 4, No. APR.
@article{0450ae55aec94929aa218be53e0171b5,
title = "Regulation of inflammation by adenosine",
abstract = "Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its receptors as feedback regulators of inflammation has been well established. Here we review the effects of adenosine, acting at its receptors, on neutrophil and monocyte/macrophage function in inflammation. Moreover, we review the role of adenosine in mediating the anti-inflammatory effects of methotrexate, the anchor drug in the treatment of Rheumatoid Arthritis and other inflammatory disorders.",
keywords = "Adenosine, Adenosine receptors, Macrophages, Monocytes, Neutrophils",
author = "G. Hask{\'o} and Bruce Cronstein",
year = "2013",
doi = "10.3389/fimmu.2013.00085",
language = "English",
volume = "4",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "APR",

}

TY - JOUR

T1 - Regulation of inflammation by adenosine

AU - Haskó, G.

AU - Cronstein, Bruce

PY - 2013

Y1 - 2013

N2 - Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its receptors as feedback regulators of inflammation has been well established. Here we review the effects of adenosine, acting at its receptors, on neutrophil and monocyte/macrophage function in inflammation. Moreover, we review the role of adenosine in mediating the anti-inflammatory effects of methotrexate, the anchor drug in the treatment of Rheumatoid Arthritis and other inflammatory disorders.

AB - Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its receptors as feedback regulators of inflammation has been well established. Here we review the effects of adenosine, acting at its receptors, on neutrophil and monocyte/macrophage function in inflammation. Moreover, we review the role of adenosine in mediating the anti-inflammatory effects of methotrexate, the anchor drug in the treatment of Rheumatoid Arthritis and other inflammatory disorders.

KW - Adenosine

KW - Adenosine receptors

KW - Macrophages

KW - Monocytes

KW - Neutrophils

UR - http://www.scopus.com/inward/record.url?scp=84883698279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883698279&partnerID=8YFLogxK

U2 - 10.3389/fimmu.2013.00085

DO - 10.3389/fimmu.2013.00085

M3 - Article

VL - 4

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - APR

M1 - Article 85

ER -