Regulation of endocannabinoid release by G proteins

A paracrine mechanism of G protein-coupled receptor action

Pál Gyombolai, Dorottya Pap, Gábor Turu, Kevin J. Catt, G. Bagdy, L. Hunyady

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In the past years, the relationship between the endocannabinoid system (ECS) and other hormonal and neuromodulatory systems has been intensively studied. G protein-coupled receptors (GPCRs) can stimulate endocannabinoid (eCB) production via activation of G q/11 proteins and, in some cases, G s proteins. In this review, we summarize the pathways through which GPCR activation can trigger eCB release, as well as the best known examples of this process throughout the body tissues. Angiotensin II-induced activation of AT 1 receptors, similar to other G q/11-coupled receptors, can lead to the formation of 2-arachidonoylglycerol (2-AG), an important eCB. The importance of eCB formation in angiotensin II action is supported by the finding that the hypertensive effect of angiotensin II, injected directly into the hypothalamic paraventricular nucleus of anaesthetized rats, can be abolished by AM251, an inverse agonist of CB 1 cannabinoid receptors (CB 1Rs). We conclude that activation of the ECS should be considered as a general consequence of the stimulation of G q/11-coupled receptors, and may mediate some of the physiological effects of GPCRs.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume353
Issue number1-2
DOIs
Publication statusPublished - Apr 28 2012

Fingerprint

Endocannabinoids
Staphylococcal Protein A
G-Protein-Coupled Receptors
GTP-Binding Proteins
Chemical activation
Angiotensin II
Cannabinoid Receptors
Paraventricular Hypothalamic Nucleus
Rats
Proteins
Tissue

Keywords

  • Angiotensin II
  • CB1
  • Endocannabinoid
  • GPCR

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

Regulation of endocannabinoid release by G proteins : A paracrine mechanism of G protein-coupled receptor action. / Gyombolai, Pál; Pap, Dorottya; Turu, Gábor; Catt, Kevin J.; Bagdy, G.; Hunyady, L.

In: Molecular and Cellular Endocrinology, Vol. 353, No. 1-2, 28.04.2012, p. 29-36.

Research output: Contribution to journalArticle

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