Regulation of brain water and electrolyte contents: The possible involvement of central atrial natriuretic factor

T. Doczi, F. Joo, P. Szerdahelyi, M. Bodosi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The intraventricular administration of 0.2 or 2μg of synthetic rat atrial natriuretic factor (syn rANF), sequence 101-126 of the precursor, prevented the water accumulation elicited in rat brain by a systemic hypoosmolar fluid load and led to a statistically significant sodium loss from the nervous tisseue, while the potassium content remained unaltered. Similar syn rANF administration to rats not treated with a hypoosmolar fluid load caused no significant change in the water, potassium, and sodium content of the hemispheres. In this experiment, a primary systemic action of centrally administered syn rANF with ensuing secondary changes in brain ion and water homeostasis seems unlikely, as the serum osmolality and sodium and potassium concentrations remained unaltered. Thus, a central influence of the intraventricularly administered hormone upon the water and ion balances of the nervous tissue can be hypothesized. The significant loss of sodium may reflect the primary role of volume regulation of the nervous tissue, i.e., the loss of extracellular osmols such as Na+ in response to a hypoosmolar environment. These data lend further support to the concept that a central neuroendocrine system regulates brain ion and volume homeostasis. The possible role of ANF in the management of brain edema should be considered.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalNeurosurgery
Volume21
Issue number4
DOIs
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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