Regulation of B cell functions by Toll-like receptors and complement

Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Erdei

Research output: Contribution to journalArticle

4 Citations (Scopus)


B cell functions triggered by the clonally-rearranged antigen-specific B cell receptor (BCR) are regulated by several germ-line encoded receptors – including Toll-like receptors (TLRs) and complement receptors (CRs). Simultaneous or sequential engagement of these structures expressed either on the cell membrane or intracellularly, may fundamentally alter and fine tune activation, antibody and cytokine production of B cells. Here we review the expression and function of TLRs and various C3 fragment binding CRs on B cells, emphasizing their role in different human B cell subsets under physiological and pathological conditions. Studies underlining the importance of the crosstalk between TLRs and CRs in regulating B cell functions are also highlighted.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalImmunology letters
Publication statusPublished - Oct 1 2016


  • B cells
  • Complement system
  • Crosstalk
  • TLR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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