Regulation of antibody production mediated by Fcγ receptors, IgG binding factors, and IgG Fc-binding autoantibodies

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Abstract

Fc receptors (FcRs) are immunoglobulin-binding structures that enable antibodies to perform a variety of functions by forming connections between specific recognition and effector cells. Besides eliciting cytotoxicity, inducing secretion of mediators and endocytosis of opsonized particles, FcRs are involved in the regulation of antibody production, both as integral membrane proteins and as soluble molecules released from the cell surface. Most FcRs belong to the same family of proteins as their ligands (immunoglobulin superfamily). This review contains recent data obtained by use of monoclonal antibodies and cloning studies on FcRs and FcR-like molecules. The importance of fine specificity of receptor binding site(s) - that of the conformation of FcRs and their ligands in triggering signaling mechanisms - is analyzed. The regulatory function of membrane-bound and -released FcRs; the correlation between cell cycle, FcR expression, and release; as well as the possible mechanisms of these phenomena are discussed.

Original languageEnglish
Pages (from-to)191-225
Number of pages35
JournalCritical Reviews in Biochemistry and Molecular Biology
Volume27
Issue number3
Publication statusPublished - 1992

Fingerprint

Fc Receptors
Autoantibodies
Antibody Formation
Immunoglobulin G
Antibodies
Immunoglobulins
Ligands
Immunoglobulin Fc Fragments
Molecules
Cloning
Cytotoxicity
Endocytosis
Conformations
immunoglobulin-binding factors
Organism Cloning
Cell Cycle
Membrane Proteins
Binding Sites
Monoclonal Antibodies
Cells

Keywords

  • B cell regulation
  • Fc receptors
  • IgG binding factor
  • Rheumatoid factor

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

Cite this

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abstract = "Fc receptors (FcRs) are immunoglobulin-binding structures that enable antibodies to perform a variety of functions by forming connections between specific recognition and effector cells. Besides eliciting cytotoxicity, inducing secretion of mediators and endocytosis of opsonized particles, FcRs are involved in the regulation of antibody production, both as integral membrane proteins and as soluble molecules released from the cell surface. Most FcRs belong to the same family of proteins as their ligands (immunoglobulin superfamily). This review contains recent data obtained by use of monoclonal antibodies and cloning studies on FcRs and FcR-like molecules. The importance of fine specificity of receptor binding site(s) - that of the conformation of FcRs and their ligands in triggering signaling mechanisms - is analyzed. The regulatory function of membrane-bound and -released FcRs; the correlation between cell cycle, FcR expression, and release; as well as the possible mechanisms of these phenomena are discussed.",
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AU - Gergely, J.

AU - Sármay, G.

AU - Rajnavolgyi, E.

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N2 - Fc receptors (FcRs) are immunoglobulin-binding structures that enable antibodies to perform a variety of functions by forming connections between specific recognition and effector cells. Besides eliciting cytotoxicity, inducing secretion of mediators and endocytosis of opsonized particles, FcRs are involved in the regulation of antibody production, both as integral membrane proteins and as soluble molecules released from the cell surface. Most FcRs belong to the same family of proteins as their ligands (immunoglobulin superfamily). This review contains recent data obtained by use of monoclonal antibodies and cloning studies on FcRs and FcR-like molecules. The importance of fine specificity of receptor binding site(s) - that of the conformation of FcRs and their ligands in triggering signaling mechanisms - is analyzed. The regulatory function of membrane-bound and -released FcRs; the correlation between cell cycle, FcR expression, and release; as well as the possible mechanisms of these phenomena are discussed.

AB - Fc receptors (FcRs) are immunoglobulin-binding structures that enable antibodies to perform a variety of functions by forming connections between specific recognition and effector cells. Besides eliciting cytotoxicity, inducing secretion of mediators and endocytosis of opsonized particles, FcRs are involved in the regulation of antibody production, both as integral membrane proteins and as soluble molecules released from the cell surface. Most FcRs belong to the same family of proteins as their ligands (immunoglobulin superfamily). This review contains recent data obtained by use of monoclonal antibodies and cloning studies on FcRs and FcR-like molecules. The importance of fine specificity of receptor binding site(s) - that of the conformation of FcRs and their ligands in triggering signaling mechanisms - is analyzed. The regulatory function of membrane-bound and -released FcRs; the correlation between cell cycle, FcR expression, and release; as well as the possible mechanisms of these phenomena are discussed.

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