Angiogenesis is a process in which new blood vessels emerge from a preexisting vascular tree. Increased angiogenesis is associated with a number of pathologic states most notably malignancy, therefore, inhibition of the angiogenic process offers treatment options for tumor growth and metastasis. In this review, the sequential steps that are involved in construction of a new vascular network are detailed together with their spatial and temporal regulation. Thereafter, possible therapeutic interventions are shown that target certain aspects of the angiogenic process. While at present angiogenesis-inhibition is barely utilized in the clinical setting, as basic knowledge about its control increases, it is predicted that the use of anti-angiogenic agents will increasingly participate in the treatment of malignancy and other conditions where enhanced angiogenesis is a part of the pathologic process.
|Translated title of the contribution||Regulation of angiogenesis and clinical aspects of its inhibition|
|Number of pages||18|
|Publication status||Published - Dec 1 2001|
ASJC Scopus subject areas