Regulation of activator protein-1-DNA binding activity by opioid peptides in estrogen-sensitive cells of rat hypothalamus and uterus

Angéla Oszter, Beáta Törocsik, Zsuzsanna Vértes, József L. Környei, Kálmán A. Kovács, Marietta Vértes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present studies demonstrate, for the first time, that the binding of activator protein-1 (AP-1)-DNA in rat uterus and the estrogen-sensitive areas of the hypothalamus, as measured by electrophoretic mobility shift assay, is increased 2 h after intraperitoneal injection of [D-Met2,Pro5]enkephalinamide. The effect was prevented by the opiate antagonist naltrexone given 30 min before the administration of [D-Met2,Pro5]enkephalinamide, suggesting the involvement of opioid peptide receptors in the observed effects. The present findings support the role of opioid peptides in the regulation of transcription in estrogen-sensitive cells. Copyright (C) 2000.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalEuropean Journal of Pharmacology
Volume395
Issue number2
DOIs
Publication statusPublished - Apr 28 2000

Keywords

  • AP-1 (activator protein-1)
  • Electrophoretic mobility shift assay
  • Hypothalamus, rat
  • Opioid peptide
  • Transcriptional regulation
  • Uterus

ASJC Scopus subject areas

  • Pharmacology

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