Regulation and termination of NADPH oxidase activity

T. E. DeCoursey, E. Ligeti

Research output: Contribution to journalReview article

185 Citations (Scopus)

Abstract

NADPH oxidase of phagocytes plays a crucial role in host defense by producing reactive oxygen species (ROS) that are intended to kill invading microbes. Many other cells produce ROS for signaling purposes. The respiratory burst oxidase in human neutrophils is the main but not exclusive subject of this review, because it is archetypical and has been studied most extensively. The activity of this enzyme must be controlled in phagocytes to prevent collateral damage, and in non-phagocytic cells to perform its signaling role. With many stimuli, NADPH oxidase activity is transient. Various forms of evidence indicate that sustained NADPH oxidase activity requires continuous renewal of the enzyme complex, without which rapid deactivation occurs. This review considers mechanisms that have been proposed to terminate the phagocyte respiratory burst. Changes in the phosphorylation state of p47phox and in the species of nucleotide bound to Rac seem to be the dominant factors in deactivation.

Original languageEnglish
Pages (from-to)2173-2193
Number of pages21
JournalCellular and Molecular Life Sciences
Volume62
Issue number19-20
DOIs
Publication statusPublished - Oct 1 2005

Keywords

  • G proteins
  • Leukocytes
  • Neutrophil
  • Phagocytes
  • Phosphatase
  • Rac
  • Reactive oxygen species
  • Respiratory burst

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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