Regression of autophagic vacuoles in seminal vesicle cells following cycloheximide treatment

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Abstract

A 0.25% fraction of cytoplasm was present in the autophagic vacuole compartment of the seminal vesicle cells of fasted and estrogen-treated mice. Autophagic vacuoles regressed rapidly after administration of 0.2 mg/g body weight cycloheximide to the animals and the decay appeared to follow first-order kinetics (average half-life 5.8 min, rate constant of regression 0.120 min-1). Our observations suggest that the drug suppressed the formation of autophagosomes. The fraction of cytoplasm removed by autophagy from the cells was estimated to be about 1.8%/h under steady-state conditions.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalExperimental Cell Research
Volume144
Issue number1
DOIs
Publication statusPublished - 1983

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Seminal Vesicles
Cycloheximide
Vacuoles
Cytoplasm
Autophagy
Half-Life
Estrogens
Body Weight
Pharmaceutical Preparations
Autophagosomes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regression of autophagic vacuoles in seminal vesicle cells following cycloheximide treatment. / Kovács, J.

In: Experimental Cell Research, Vol. 144, No. 1, 1983, p. 231-234.

Research output: Contribution to journalArticle

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