Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine: An efficient one-pot transformation of thebaine to (R)(-)-2-meihoxyapomorphine

Sándor Berényi, Csaba Csutorás, Susanna Gyulai, Sándor Makleit

Research output: Contribution to journalArticle

6 Citations (Scopus)


2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-de-methylation of aporphine derivatives.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalSynthetic Communications
Issue number3
Publication statusPublished - Feb 1 1995


ASJC Scopus subject areas

  • Organic Chemistry

Cite this