Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine

An efficient one-pot transformation of thebaine to (R)(-)-2-methoxyapomorphine

S. Berenyi, C. Csutorás, S. Gyulai, S. Makleit

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-demethylation of aporphine derivatives.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalSynthetic Communications
Volume25
Issue number3
Publication statusPublished - 1995

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Aporphines
Thebaine
Methionine
Derivatives
methanesulfonic acid
aporphine
2-methoxyapomorphine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

@article{1547e76d989d43f288b2b23d94afaf71,
title = "Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine: An efficient one-pot transformation of thebaine to (R)(-)-2-methoxyapomorphine",
abstract = "2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-demethylation of aporphine derivatives.",
author = "S. Berenyi and C. Csutor{\'a}s and S. Gyulai and S. Makleit",
year = "1995",
language = "English",
volume = "25",
pages = "283--288",
journal = "Synthetic Communications",
issn = "0039-7911",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine

T2 - An efficient one-pot transformation of thebaine to (R)(-)-2-methoxyapomorphine

AU - Berenyi, S.

AU - Csutorás, C.

AU - Gyulai, S.

AU - Makleit, S.

PY - 1995

Y1 - 1995

N2 - 2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-demethylation of aporphine derivatives.

AB - 2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-demethylation of aporphine derivatives.

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UR - http://www.scopus.com/inward/citedby.url?scp=0028816670&partnerID=8YFLogxK

M3 - Article

VL - 25

SP - 283

EP - 288

JO - Synthetic Communications

JF - Synthetic Communications

SN - 0039-7911

IS - 3

ER -