Regioselective O-demethylation of aporphines with methanesulfonic acid/methionine: An efficient one-pot transformation of thebaine to (R)(-)-2-meihoxyapomorphine

Sándor Berényi, Csaba Csutorás, Susanna Gyulai, Sándor Makleit

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6 Citations (Scopus)

Abstract

2-Methoxyapomorphine (4) was obtained by the rearrangement of thebaine (1) with methanesulfonic acid in the presence of methionine, a reagent system suitable for the regioselective O-de-methylation of aporphine derivatives.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalSynthetic Communications
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 1 1995

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ASJC Scopus subject areas

  • Organic Chemistry

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