Regioselective catalytic deuteriation of phospholipids - Unusual mechanistic aspects of homogeneous hydrogenation

Balázs Szalontai, Ferenc Joó, Éva Papp, László Vígh

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Abstract

Reaction of unsaturated phospholipids, R1HC=CHR2, with D2 in aqueous (H2O) dispersions with Pd II-alizarin red as the catalyst results in formation of R 1H2C-CD2R2 (in addition to the expected R1HDC-CDHR2); however, only the latter is formed with H2 in D2O, which reveals the importance of the reversible formation of an intermediate alkylmetal species.

Original languageEnglish
Pages (from-to)2299-2300
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number22
DOIs
Publication statusPublished - Dec 1 1995

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ASJC Scopus subject areas

  • Molecular Medicine

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