Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia

A voxel-based morphometric study

R. Herold, Á Feldmann, M. Simón, T. Tényi, F. Kövér, F. Nagy, E. Varga, S. Fekete

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalActa Psychiatrica Scandinavica
Volume119
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Theory of Mind
Schizophrenia
Prefrontal Cortex
Temporal Lobe
Healthy Volunteers
Gray Matter
Brain

Keywords

  • Frontal lobe
  • Schizophrenia
  • Temporal lobe
  • Theory of mind
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia : A voxel-based morphometric study. / Herold, R.; Feldmann, Á; Simón, M.; Tényi, T.; Kövér, F.; Nagy, F.; Varga, E.; Fekete, S.

In: Acta Psychiatrica Scandinavica, Vol. 119, No. 3, 03.2009, p. 199-208.

Research output: Contribution to journalArticle

@article{8df2ebddbfce443786c0c66721c75801,
title = "Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: A voxel-based morphometric study",
abstract = "Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.",
keywords = "Frontal lobe, Schizophrenia, Temporal lobe, Theory of mind, Voxel-based morphometry",
author = "R. Herold and {\'A} Feldmann and M. Sim{\'o}n and T. T{\'e}nyi and F. K{\"o}v{\'e}r and F. Nagy and E. Varga and S. Fekete",
year = "2009",
month = "3",
doi = "10.1111/j.1600-0447.2008.01297.x",
language = "English",
volume = "119",
pages = "199--208",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia

T2 - A voxel-based morphometric study

AU - Herold, R.

AU - Feldmann, Á

AU - Simón, M.

AU - Tényi, T.

AU - Kövér, F.

AU - Nagy, F.

AU - Varga, E.

AU - Fekete, S.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.

AB - Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.

KW - Frontal lobe

KW - Schizophrenia

KW - Temporal lobe

KW - Theory of mind

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=58849103046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849103046&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0447.2008.01297.x

DO - 10.1111/j.1600-0447.2008.01297.x

M3 - Article

VL - 119

SP - 199

EP - 208

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 3

ER -