Regional distribution of [3H]imipramine binding in rat brain

Miklos Palkovits, Rita Raisman, Michael Briley, Salomon Z. Langer

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

[3H]imipramine binding was measured in 23 microdissected areas of the rat brain and compared to published values for the endogenous levels of serotonin, noradrenaline and dopamine in the same areas. The density of [3H]imipramine binding sites appears to be highly correlated with the distribution of endogenous serotonin especially where the serotonin is located mainly in nerve terminals. A weak but still significant correlation also exists with the distribution of endogenous noradrenaline whereas no such correlation could be detected for endogenous dopamine.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalBrain research
Volume210
Issue number1-2
DOIs
Publication statusPublished - Apr 6 1981

Keywords

  • dopamine
  • imipramine binding
  • neurotransmitter distribution
  • noradrenaline
  • rat brain
  • receptor distribution
  • serotonin
  • tricyclic antidepressant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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