Regional distribution of substance P-like immunoreactivity in the lower brainstem of the rat

Frank L. Douglas, Miklós Palkovits, Michael J. Brownstein

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Abstract

A radioimmunoassay was used to quantify substance P-like immunoreactivity in the lower brainstem of the rat. The peptide was detectable in all brainstem nuclei investigated. A very high concentration was found in the substantia nigra, and high concentrations in the interpeduncular nucleus and central gray matter. Levels in the pons, the parabrachial nuclei; in the medulla, the nucleus tractus spinalis of the Vth nerve and the nucleus of the solitary tract were higher than the brain average.

Original languageEnglish
Pages (from-to)376-378
Number of pages3
JournalBrain research
Volume245
Issue number2
DOIs
Publication statusPublished - Aug 12 1982

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Keywords

  • brainstem
  • radioimmunoassay
  • substance P

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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