Regional Disease Control in Selected Patients with Sentinel Lymph Node Involvement and Omission of Axillary Lymph Node Dissection

G. Cserni, Róbert Maráz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Whether an axillary lymph node dissection (ALND) is needed for breast cancer patients with minimal sentinel lymph node (SLN) involvement is arguable despite recent data supporting the omission of axillary clearance in these patients. Data on disease recurrence of 111 patients with SLN involvement and no ALND were analysed. Patients with minimal SLN involvement were assessed for their risk of non-SLN metastasis by means of several nomograms. The series included patients with isolated tumour cells (n = 76), micrmetastasis (n = 33) and macrometastasis (n = 2) who were followed for a median of 37 months (range 12–148 months). Six patients died, 3 of disease and 3 of unrelated causes. Eight further patients had breast cancer related events: 1 local breast recurrence and seven distant metastases. No axillary regional recurrence was detected. Disease related events were not associated with the risk of non-SLN metastasis. The presented data suggest that omitting ALND in patients with low volume SLN metastasis may be a safe procedure, and support the observation that systemic disease recurrence may not be associated with axillary recurrence or the risk of NSLN involvement predicted by nomograms.

Original languageEnglish
Pages (from-to)861-866
Number of pages6
JournalPathology and Oncology Research
Volume21
Issue number4
DOIs
Publication statusPublished - Sep 28 2015

Fingerprint

Lymph Node Excision
Recurrence
Neoplasm Metastasis
Nomograms
Lymph Nodes
Breast Neoplasms
Sentinel Lymph Node
Breast
Neoplasms

Keywords

  • Axillary lymph node dissection
  • Follow-up
  • Isolated tumour cells/clusters
  • Micrometastasis
  • Sentinel lymph node

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Regional Disease Control in Selected Patients with Sentinel Lymph Node Involvement and Omission of Axillary Lymph Node Dissection. / Cserni, G.; Maráz, Róbert.

In: Pathology and Oncology Research, Vol. 21, No. 4, 28.09.2015, p. 861-866.

Research output: Contribution to journalArticle

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