Regional differences in the neuronal expression of cyclooxygenase-2 (COX-2) in the newborn pig brain

Orsolya Oláh, István Németh, Valéria Tóth-Szuki, F. Bari, F. Domoki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cycoxygene (COX-2 is the major costitutively expressed COX isoform in the newborn brain. COX-2 derived prostanoids and reactive oxygen species appear to play a major role in the mechanism of perinatal hypoxic-ischemic injury in the newborn piglet, an accepted animal model of the human term neonate. The study aimed to quantitatively determine COX-2 immunopositive neurons in different brain regions in piglets under normoxic conditions (n=15), and 4 hours after 10 min asphyxia (n=11). Asphyxia did not induce significant changes in neuronal COX-2 expression of any studied brain areas. In contrast, there was a marked regional difference in all experimental groups. Thus, significant difference was observed between fronto-parietal and temporo-occipital regions: 59±4% and 67±3% versus 41±2%* and 31±3%* respectively (mean±SEM, data are pooled from all subjects, n=26, *p

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalActa Histochemica et Cytochemica
Volume45
Issue number3
DOIs
Publication statusPublished - 2012

Fingerprint

Cyclooxygenase 2
Brain
Swine
Asphyxia
Occipital Lobe
Neurons
Prostaglandins
Reactive Oxygen Species
Protein Isoforms
Animals
Animal Models
Wounds and Injuries

Keywords

  • Cerebral cortex
  • Hippocampus
  • Immuno-histochemistry
  • Neonatal pig
  • Prostaglandin H synthase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Regional differences in the neuronal expression of cyclooxygenase-2 (COX-2) in the newborn pig brain. / Oláh, Orsolya; Németh, István; Tóth-Szuki, Valéria; Bari, F.; Domoki, F.

In: Acta Histochemica et Cytochemica, Vol. 45, No. 3, 2012, p. 187-192.

Research output: Contribution to journalArticle

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AU - Bari, F.

AU - Domoki, F.

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