Regional cortical blood flow changes following sodium lactate infusion in Alzheimer's disease

János Kálmán, András Palotás, Gabriella Kis, Krisztina Boda, Piroska Túri, Ferenc Bari, Ferenc Domoki, Ildikó Dóda, Miklós Árgyelán, Gábor Vincze, Teréz Séra, László Csernay, Zoltán Janka, László Pávics

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bilateral temporoparietal hypoperfusion is a characteristic single photon emission computed tomography (SPECT) finding in Alzheimer's disease (AD). Lactate is a metabolic vasodilator and is known to provoke increased cerebral blood flow (CBF) in healthy adults. This work investigated whether lactate, which is present in high concentrations in AD cerebrospinal fluid, affects AD-specific perfusion abnormalities. Twenty mild-to-moderately demented AD probands participated in the self-controlled study. The regional CBF was examined utilizing 99mTc-HMPAO SPECT after sodium lactate infusion (0.5 M, 5 mL/kg body weight) and 0.9% NaCl infusion, one on each of two separate days. Despite the vasodilatator effects of sodium lactate, AD rCBF patterns did not show increase in temporo-parietal regions after its infusion. AD-specific bi-temporo-parietal reduction in CBF was accompanied by further hypoperfusion in the parieto-occipital areas after the sodium lactate infusion in seven patients, while no CBF changes were observed in the case of the remaining 13 probands. The pattern of the CBF abnormalities was not correlated with the apolipoprotein E genotype. The decreased vascular responsiveness to sodium lactate reflects disturbed vasoregulatory processes in AD and it is unlikely that lactate would have any relevance in the treatment of AD-related cerebral hypoperfusion, but could be used to improve the value of perfusion SPECT in the diagnosis of AD.

Original languageEnglish
Pages (from-to)1671-1678
Number of pages8
JournalEuropean Journal of Neuroscience
Volume21
Issue number6
DOIs
Publication statusPublished - Mar 1 2005

Keywords

  • Alzheimer's disease
  • Cerebral blood flow
  • Lactate
  • SPECT
  • Stress reaction
  • Vascular reactivity
  • Vasoregulation

ASJC Scopus subject areas

  • Neuroscience(all)

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